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Cocaine elicited a pressor response in mixed responders (MR) that was dependent on small increases in both SVR and CO. ANG II (30 ng\/5 \u03bcl icv, 5 min before cocaine) augmented the decrease in CO in VR and prevented the increase in CO in MR. Administration of [Sar<jats:sup>1<\/jats:sup>,Thr<jats:sup>8<\/jats:sup>]ANG II (20 \u03bcg\/5 \u03bcl icv; sarthran) before cocaine attenuated the decrease in CO and the large increase in SVR in VR so that they were no longer different from MR. Losartan (20 \u03bcg icv) or captopril (50 \u03bcg icv) preceding cocaine administration also attenuated the decrease in CO and the large increase in SVR seen in VR only. The role of angiotensin was not specific for cocaine, because ANG II (icv) pretreatment before startle with cold water (1 cm deep) enhanced the decrease in CO and the increase in SVR in both MR and VR, whereas losartan (icv) pretreatment before startle attenuated the decrease in CO and the increase in SVR in VR so that they were no longer different from MR. These data suggest that central ANG II receptors mediate the greater vascular and cardiac responsiveness in vascular responders to acute pharmacological and behavioral stressors. <\/jats:p>","DOI":"10.1152\/ajpregu.00825.2005","type":"journal-article","created":{"date-parts":[[2006,4,7]],"date-time":"2006-04-07T00:54:41Z","timestamp":1144371281000},"page":"R719-R727","source":"Crossref","is-referenced-by-count":6,"title":["Central angiotensin II receptors mediate hemodynamic response variability to stressors"],"prefix":"10.1152","volume":"291","author":[{"given":"Kayla D.","family":"Rowe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance L.","family":"Lomax","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark M.","family":"Knuepfer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","unstructured":"Branch CA and Knuepfer MM. 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