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A microdialysis probe was inserted into the DMM of anesthetized adult mice. Each mouse was placed in a double-chamber plethysmograph. After recovery from anesthesia, the mice were exposed to stepwise increases in CO<jats:sub>2<\/jats:sub>inhalation (5%, 7%, and 9% CO<jats:sub>2<\/jats:sub>in O<jats:sub>2<\/jats:sub>) at 8-min intervals with a selective serotonin reuptake inhibitor, fluoxetine, or fluoxetine plus a 5-HT2 receptor antagonist, LY-53857 in the DMM. In response to fluoxetine plus LY-53857 coperfusion, specific airway resistance was increased, and tidal volume and minute ventilation were decreased. CO<jats:sub>2<\/jats:sub>inhalation with fluoxetine plus LY-53857 coperfusion in the DMM largely decreased airway resistance and additively increased minute ventilation. Thus, 5-HT2 receptor activity in the DMM increases basal levels of airway dilation and ventilatory volume, dependent on central inspiratory activity and the volume threshold of the inspiratory off-switch mechanism. Hypercapnia with low 5-HT2 receptor activity in the DMM largely recovers airway dilation and additively increases ventilatory volume. Interaction between 5-HT2 receptor activity in the DMM and CO<jats:sub>2<\/jats:sub>drive may elicit a cycle of hyperventilation with airway dilation and hypoventilation with airway narrowing.<\/jats:p>","DOI":"10.1152\/ajpregu.00829.2006","type":"journal-article","created":{"date-parts":[[2007,5,31]],"date-time":"2007-05-31T00:35:47Z","timestamp":1180571747000},"page":"R854-R860","source":"Crossref","is-referenced-by-count":28,"title":["Compensatory airway dilation and additive ventilatory augmentation mediated by dorsomedial medullary 5-hydroxytryptamine 2 receptor activity and hypercapnia"],"prefix":"10.1152","volume":"293","author":[{"given":"Mitsuko","family":"Kanamaru","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuo","family":"Homma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1974.tb05753.x"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91605-G"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1972.sp009797"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200411000-00021"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.6.2440"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Ejlersen E, Andersen HB, Eliasen K, Mogensen T.A comparison between preincisional and postincisional lidocaine infiltration and postoperative pain.Anesth Analg74: 495\u2013498, 1992.","DOI":"10.1213\/00000539-199204000-00004"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200202-107OC"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200412-1750OC"},{"key":"R9","unstructured":"Garay SM, Rapoport D, Sorkin B, Epstein H, Feinberg I, Goldring RM.Regulation of ventilation in the obstructive sleep apnea syndrome.Am Rev Respir Dis124: 451\u2013457, 1981."},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1038\/nature03690"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2004.029637"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.2.416"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(01)00290-0"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.152.1.7599822"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2000.89.2.770"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00273.2002"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(93)90090-9"},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Jansen AH, Nance DM, Liu P, Weisman H, Chernick V.Effect of sinus denervation and vagotomy on c-fos expression in the nucleus tractus solitarius after exposure to CO2.Pfl\u00fcgers Arch431: 876\u2013881, 1996.","DOI":"10.1007\/BF02332172"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0467f.x"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200505-790OC"},{"key":"R21","unstructured":"Kraiczi H, Hedner J, Dahlof P, Ejnell H, Carlson J.Effect of serotonin uptake inhibition on breathing during sleep and daytime symptoms in obstructive sleep apnea.Sleep22: 61\u201367, 1999."},{"key":"R22","unstructured":"Kubin L, Davies RO.Mechanisms of arway hypotonia. 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