{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:45:11Z","timestamp":1791279911737,"version":"4.1.0"},"reference-count":48,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p> The present strategy for the prevention of excessive sympathetic neural traffic to the heart relies on the use of beta-blockers, drugs that act at the heart end of the brain-heart axis. In the present study, we attempted to suppress cardiac sympathetic nerve activity by affecting the relevant cardiomotoneurons in the brain using the selective serotonin-1A (5-HT<jats:sub>1A<\/jats:sub>) receptor agonist 8-hydroxy-2-(di- n-propylamino)tetralin (8-OH-DPAT). In conscious, unrestrained rabbits, instrumented for recordings of heart rate, arterial pressure, or cardiac output, we provoked increases in cardiac sympathetic activity by psychological (loud sound, pinprick, and air jet) or inflammatory (0.5 \u03bcg\/kg iv lipopolysaccharide) stresses. Pinprick and air-jet stresses elicited transient increases in heart rate (+50 \u00b1 7 and +38 \u00b1 4 beats\/min, respectively) and in mean arterial pressure (+16 \u00b1 2 and +15 \u00b1 3 mmHg, respectively). Lipopolysaccharide injection caused sustained increases in heart rate (from 210 \u00b1 3 to 268 \u00b1 10 beats\/min) and in arterial pressure (from 74 \u00b1 3 to 92 \u00b1 4 mmHg). Systemically administered 8-OH-DPAT (0.004\u20130.1 mg\/kg) substantially attenuated these responses in a dose-dependent manner. Drug effects were prevented by a selective 5-HT<jats:sub>1A<\/jats:sub> receptor antagonist, WAY-100635 (0.1 mg\/kg iv). Similarly to systemic administration, microinjection of 8-OH-DPAT (500 nl of 10 mM solution) into the medullary raphe-parapyramidal region caused antitachycardic effects during stressful stimulation and during lipopolysaccharide-elicited tachycardia. This is the first demonstration that activation of 5-HT<jats:sub>1A<\/jats:sub> receptors in the medullary raphe-parapyramidal area causes suppression of neurally mediated cardiovascular changes during acute psychological and immune stresses. <\/jats:p>","DOI":"10.1152\/ajpregu.00845.2004","type":"journal-article","created":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T01:37:24Z","timestamp":1112319444000},"page":"R596-R604","source":"Crossref","is-referenced-by-count":60,"title":["Activation of 5-HT<sub>1A<\/sub> receptors in the medullary raphe reduces cardiovascular changes elicited by acute psychological and inflammatory stresses in rabbits"],"prefix":"10.1152","volume":"289","author":[{"given":"Eugene","family":"Nalivaiko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youichirou","family":"Ootsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Blessing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-3306.1996.tb03090.x"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(98)00102-0"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.44.5.723"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.09.021"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-2-00279.x"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00459-0"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.03.013"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)90869-D"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.6.2322"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Dabire H, Laubie M, and Schmitt H. Hypotensive effects of 5-HT1A receptor agonists on the ventrolateral medullary pressor area in dogs. J Cardiovasc Pharmacol 15, Suppl 7: S61\u2013S67, 1990.","DOI":"10.1097\/00005344-199000157-00008"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(88)90789-3"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00234-C"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-198703000-00010"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200112000-00001"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1007\/BF00216019"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1007\/BF01252244"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19970310)379:2<261::AID-CNE7>3.0.CO;2-1"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(93)90048-Y"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1989.tb11896.x"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90140-L"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(89)90005-2"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00515.2003"},{"key":"R23","unstructured":"McCall RB and Clement ME. Role of serotonin 1A and serotonin 2 receptors in the central regulation of the cardiovascular system. Pharmacol Rev 46: 231\u2013243, 1994."},{"key":"R24","unstructured":"McCall RB, Patel BN, and Harris LT. Effects of serotonin 1 and serotonin 2 receptor agonists and antagonists on blood pressure, heart rate and sympathetic nerve activity. J Pharmacol Exp Ther 242: 1152\u20131159, 1987."},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2003.02379.x"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00678.2003"},{"key":"R27","doi-asserted-by":"crossref","unstructured":"Morrison SF. Central pathways controlling brown adipose tissue thermogenesis. News Physiol Sci 19: 67\u201374, 2004.","DOI":"10.1152\/nips.01502.2003"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.05.062"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03210-8"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-003-0448-1"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1991.260.3.R600"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050333"},{"key":"R33","doi-asserted-by":"crossref","unstructured":"Ootsuka Y and Blessing WW. 5-Hydroxytryptamine 1A receptors inhibit cold-induced sympathetically-mediated cutaneous vasoconstriction in rabbits. J Physiol 552.1: 303\u2013314, 2003.","DOI":"10.1113\/jphysiol.2003.048041"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540-8167.2004.04388.x"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00612-8"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1981.03320030025021"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199704033361401"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.16.2192"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02484-1"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2003.12.003"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.44.693"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2001.013302"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.274.3.R814"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.1996.tb00723.x"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb12994.x"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.272.1.R208"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00047-8"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.032201"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.00845.2004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T15:56:22Z","timestamp":1567958182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.00845.2004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1152\/ajpregu.00845.2004"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.00845.2004","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}