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In the present study, we used hyperoxic tests to assess the strength of the peripheral chemoreceptor tonic drive in Phox2b+\/\u2212 newborn mice. We exposed 69 wild-type and 67 mutant mice to two hyperoxic tests (12-min air followed by 3-min 100% O<jats:sub>2<\/jats:sub>) 2 days after birth. Breathing variables were measured noninvasively using whole body flow plethysmography. The initial minute ventilation decrease was larger in mutant pups than in wild-type pups: \u221237% (SD 13) and \u221225% (SD 18), respectively, P &lt; 0.0001. Furthermore, minute ventilation remained depressed throughout O<jats:sub>2<\/jats:sub>exposure in mutants, possibly because of their previously reported impaired CO<jats:sub>2<\/jats:sub>chemosensitivity, whereas it returned rapidly to the normoxic level in wild-type pups. Hyperoxia considerably increased total apnea duration in mutant compared with wild-type pups ( P = 0.0001). A complementary experiment established that body temperature was not influenced by hyperoxia in either genotype group and, therefore, did not account for genotype-related differences in the hyperoxic ventilatory response. Thus partial loss of Phox2b function by heterozygosity did not diminish the tonic drive from peripheral chemoreceptors.<\/jats:p>","DOI":"10.1152\/ajpregu.00875.2005","type":"journal-article","created":{"date-parts":[[2006,1,13]],"date-time":"2006-01-13T02:09:21Z","timestamp":1137118161000},"page":"R1691-R1696","source":"Crossref","is-referenced-by-count":35,"title":["Ventilatory response to hyperoxia in newborn mice heterozygous for the transcription factor<i>Phox2b<\/i>"],"prefix":"10.1152","volume":"290","author":[{"given":"N.","family":"Ramanantsoa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Vaubourg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Dauger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Matrot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Vardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Chettouh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Gaultier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Goridis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gallego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2004.08.003"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1130"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.160.1.16010"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi188"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(99)00054-7"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2302(199809)33:2<107::AID-DEV2>3.0.CO;2-N"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2003.11.002"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh156"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00866"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.03.013"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200411-1528OC"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00802.2003"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00303.2003"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000115677.78759.C5"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.1.379"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1136\/adc.62.12.1238"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-201X.2004.01361.x"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780030211"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.273bi.x"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1136\/fn.73.2.F81"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000125262.82405.3C"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.1.136"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.015412"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00803.2004"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199505000-00017"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1139\/y99-001"},{"key":"R27","unstructured":"Mortola JPand Gautier H.Interaction between metabolism and ventilation: effects of respiratory gases and temperature. 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