{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:28:54Z","timestamp":1791746934007,"version":"4.3.4"},"reference-count":29,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2000,1,1]]},"abstract":"<jats:p> Mechanisms underlying the circadian rhythm in lung ventilation were investigated. Ten healthy male subjects were studied for 36 h using a constant routine protocol to minimize potentially confounding variables. Laboratory light, humidity, and temperature remained constant, subjects did not sleep, and their meals and activities were held to a strict schedule. Respiratory chemoreflex responses were measured every 3 h using an iso-oxic rebreathing technique incorporating prior hyperventilation. Subjects exhibited circadian rhythms in oral temperature and respiratory chemoreflex responses, but not in metabolic rate. Basal ventilation [i.e., at subthreshold end-tidal carbon dioxide partial pressure ([Formula: see text])] did not vary with time of day, but the ventilatory response to suprathreshold[Formula: see text] exhibited a rhythm amplitude of \u223c25%, mediated mainly by circadian variations in the CO<jats:sub>2<\/jats:sub> threshold for tidal volume. We conclude that the circadian rhythm in lung ventilation is not a simple consequence of circadian variations in arousal state and metabolic rate. By raising the chemoreflex threshold, the circadian timing system may increase the propensity for respiratory instability at night. <\/jats:p>","DOI":"10.1152\/ajpregu.2000.278.1.r282","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T23:43:05Z","timestamp":1514158985000},"page":"R282-R286","source":"Crossref","is-referenced-by-count":53,"title":["Circadian rhythms in the chemoreflex control  of breathing"],"prefix":"10.1152","volume":"278","author":[{"given":"Richard","family":"Stephenson","sequence":"first","affiliation":[{"name":"Respiratory Research Group, Departments ofPhysiology and"},{"name":"Zoology, University of Toronto, Toronto, Ontario, Canada M5S 1A1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi M.","family":"Mohan","sequence":"additional","affiliation":[{"name":"Respiratory Research Group, Departments ofPhysiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Duffin","sequence":"additional","affiliation":[{"name":"Respiratory Research Group, Departments ofPhysiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim M.","family":"Jarsky","sequence":"additional","affiliation":[{"name":"Zoology, University of Toronto, Toronto, Ontario, Canada M5S 1A1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00242287"},{"key":"B2","first-page":"144","volume":"135","author":"Berthon-Jones M.","year":"1987","journal-title":"Am. Rev. Resp. Dis."},{"key":"B3","first-page":"899","volume":"122","author":"Bowes G.","year":"1980","journal-title":"Am. Rev. Resp. Dis."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111355"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.53.4.855"},{"key":"B6","first-page":"1163","volume":"133","author":"Dempsey J. A.","year":"1986","journal-title":"Am. Rev. Resp. Dis."},{"key":"B7","first-page":"758","volume":"126","author":"Douglas N. J.","year":"1982","journal-title":"Am. Rev. Resp. Dis."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.5.1121"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1961.16.1.15"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.50.4.724"},{"key":"B11","first-page":"14","volume":"126","author":"Guilleminault C.","year":"1982","journal-title":"Am. Rev. Resp. Dis."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/19.10.827"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.4.9712105"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1177\/074873098129000255"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(86)90056-8"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1994.267.3.R819"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012582"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(97)00024-8"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(97)00056-X"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281712"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1126\/science.2305266"},{"key":"B23","first-page":"568","volume":"43","author":"Raschke F.","year":"1989","journal-title":"Pneumologie"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1139\/y95-024"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1378\/chest.84.6.695"},{"key":"B26","first-page":"A777","volume":"155","author":"Spengler C. M.","year":"1997","journal-title":"Am. J. Resp. Crit. Care Med."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1977.42.4.492"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92140-1"},{"key":"B29","first-page":"984","volume":"128","author":"White D. P.","year":"1983","journal-title":"Am. Rev. Resp. Dis."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.274.3.R686"}],"container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpregu.2000.278.1.R282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:47:21Z","timestamp":1567990041000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpregu.2000.278.1.R282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1,1]]}},"alternative-id":["10.1152\/ajpregu.2000.278.1.R282"],"URL":"https:\/\/doi.org\/10.1152\/ajpregu.2000.278.1.r282","relation":{},"ISSN":["0363-6119","1522-1490"],"issn-type":[{"value":"0363-6119","type":"print"},{"value":"1522-1490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1,1]]}}}