{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T17:03:40Z","timestamp":1715533420581},"reference-count":24,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2000,2,1]]},"abstract":"<jats:p> We studied the role of cardiac and arterial baroreceptors in the reflex control of arginine vasopressin (AVP) and renin secretion during graded hypotension in conscious dogs. The dogs were prepared with Silastic cuffs on the thoracic inferior vena cava and catheters in the pericardial space. Each experiment consisted of a control period followed by four periods of inferior vena caval constriction, during which mean arterial pressure (MAP) was reduced in increments of \u223c10 mmHg. The hormonal responses were measured in five dogs under four treatment conditions: 1) intact, 2) acute cardiac denervation (CD) by intrapericardial infusion of procaine, 3) after sinoaortic denervation (SAD), and 4) during combined SAD+CD. The individual slopes relating MAP to plasma AVP and plasma renin activity (PRA) were used to compare the treatment effects using a 2 \u00d7 2 factorial analysis. There was a significant ( P &lt; 0.01) effect of SAD on the slope relating plasma AVP to MAP but no effect of CD and no SAD \u00d7 CD interaction. In contrast, the slope relating PRA and MAP was increased ( P &lt; 0.05) by SAD but was not affected by CD. These results support the hypothesis that stimulation of AVP secretion in response to graded hypotension is primarily driven by unloading arterial baroreceptors in the dog. <\/jats:p>","DOI":"10.1152\/ajpregu.2000.278.2.r469","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T04:49:07Z","timestamp":1514177347000},"page":"R469-R475","source":"Crossref","is-referenced-by-count":16,"title":["Arterial baroreceptors control plasma vasopressin  responses to graded hypotension in conscious dogs"],"prefix":"10.1152","volume":"278","author":[{"given":"Terry N.","family":"Thrasher","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Maryland, Baltimore, Maryland 21201;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Gen","family":"Chen","sequence":"additional","affiliation":[{"name":"The Maple House, Santa Cruz 95062; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanny C.","family":"Keil","sequence":"additional","affiliation":[{"name":"National Aeronautics and Space Administration, Ames Research Center, Moffett Field, California 94035"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/1.1.67"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1976.56.1.1"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1994.266.6.R1885"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1984.247.6.F881"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1210\/endo-123-1-319"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1991.71.3.617"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1979.236.1.F66"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1210\/endo-100-1-30"},{"key":"B9","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1152\/ajplegacy.1964.207.6.1399","volume":"207","author":"Mills E.","year":"1964","journal-title":"Am. 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