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The peak response of caffeine stimulation was reduced by \u223c28% by 100 \u03bcM ryanodine in a use-dependent manner suggesting that the first 10 min of GH release is partially mediated by a caffeine-activated ryanodine receptor. The temporal sensitivities of caffeine- and dopamine-evoked GH release to blockade of Cd<jats:sup>2+<\/jats:sup>-sensitive Ca<jats:sup>2+<\/jats:sup>channels were compared. We demonstrated that the initial phase of dopamine-evoked release was dependent on Ca<jats:sup>2+<\/jats:sup>channels, whereas the initial phase of caffeine-evoked release was sensitive only to pretreatment blockade. This would suggest that the maintenance of one class of caffeine-activated intracellular stores requires entry of Ca<jats:sup>2+<\/jats:sup>through Cd<jats:sup>2+<\/jats:sup>-sensitive Ca<jats:sup>2+<\/jats:sup>channels. This differential temporal requirement for Ca<jats:sup>2+<\/jats:sup>channels in Ca<jats:sup>2+<\/jats:sup>signaling may be a mechanism to segregate intracellular signaling pathways of multiple neuroendocrine regulators in the teleost pituitary.<\/jats:p>","DOI":"10.1152\/ajpregu.2001.280.2.r494","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T05:29:49Z","timestamp":1514179789000},"page":"R494-R503","source":"Crossref","is-referenced-by-count":10,"title":["Caffeine stores and dopamine differentially require Ca<sup>2+<\/sup>channels in goldfish somatotropes"],"prefix":"10.1152","volume":"280","author":[{"given":"Calvin J. 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