{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T13:19:33Z","timestamp":1788009573662,"version":"build-2784847793"},"reference-count":35,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2001,3,1]]},"abstract":"<jats:p>\n                    CCK is a physiological inhibitor of gastric emptying and food intake. The pancreatic peptide amylin exerts similar actions, yet its physiological importance is uncertain. Objectives were to compare the dose-dependent effects of intravenous infusion of amylin and CCK-8 on gastric emptying and food intake in rats, and to assess whether physiological doses of amylin are effective. Amylin and CCK-8 inhibited gastric emptying with mean effective doses (ED\n                    <jats:sub>50<\/jats:sub>\n                    s) of 3 and 35 pmol \u00b7 kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7 min\n                    <jats:sup>\u22121<\/jats:sup>\n                    and maximal inhibitions of 60 and 65%, respectively. Amylin and CCK-8 inhibited food intake with ED\n                    <jats:sub>50<\/jats:sub>\n                    s of 8 and 14 pmol \u00b7 kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7 min\n                    <jats:sup>\u22121<\/jats:sup>\n                    and maximal inhibitions of 78 and 69%, respectively. The minimal effective amylin dose for each effect was 1 pmol \u00b7 kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00b7 min\n                    <jats:sup>\u22121<\/jats:sup>\n                    . Our previous work suggests that this dose increases plasma amylin by an amount comparable to that produced by a meal. These results support the hypothesis that amylin acts as a hormonal signal to the brain to inhibit gastric emptying and food intake and that amylin produces satiety in part through inhibition of gastric emptying.\n                  <\/jats:p>","DOI":"10.1152\/ajpregu.2001.280.3.r605","type":"journal-article","created":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T00:35:43Z","timestamp":1514162143000},"page":"R605-R611","source":"Crossref","is-referenced-by-count":79,"title":["Comparative effects of amylin and cholecystokinin on food intake and gastric emptying in rats"],"prefix":"10.1152","volume":"280","author":[{"given":"Roger D.","family":"Reidelberger","sequence":"first","affiliation":[{"name":"Veterans Affairs Medical Center, Omaha 68105; Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, Nebraska 68178; and Arvid Wretlind Laboratory for Metabolic Research, Department of Surgery, Karolinska Institutet at Huddinge University Hospital, S-14186 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