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Norepinephrine in combination with the \u03b1<jats:sub>2<\/jats:sub>-antagonist yohimbine resulted in retardation of the FFA decrease, indicating the involvement of \u03b1<jats:sub>2<\/jats:sub>-adrenoceptors. Infusion with the partial \u03b1<jats:sub>2<\/jats:sub>-agonist clonidine had a smaller effect. Infusion with isoproterenol caused a marked increase of glucose levels, and unexpectedly a decline of plasma FFA levels, indicating a direct involvement of \u03b2-adrenoceptors. Combination of isoproterenol with either atenolol (\u03b2<jats:sub>1<\/jats:sub>-antagonist) or ICI-118,551 (\u03b2<jats:sub>2<\/jats:sub>-antagonist) showed that both \u03b2<jats:sub>1<\/jats:sub>- and \u03b2<jats:sub>2<\/jats:sub>-adrenoceptors were involved in the glucose release by isoproterenol. Remarkably, the decline of FFA levels was augmented in the presence of ICI-118,551, whereas with atenolol present plasma FFA levels were increased by isoproterenol. Thus it is concluded that in carp both \u03b2<jats:sub>1<\/jats:sub>- and \u03b2<jats:sub>2<\/jats:sub>-adrenoceptors mediate glucose release, whereas lipolysis is controlled by inhibitory \u03b2<jats:sub>1<\/jats:sub>-adrenoceptors and stimulatory \u03b2<jats:sub>2<\/jats:sub>-adrenoceptors, as well as by inhibitory \u03b1<jats:sub>2<\/jats:sub>-adrenoceptors.<\/jats:p>","DOI":"10.1152\/ajpregu.2001.281.2.r615","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T12:40:34Z","timestamp":1513860034000},"page":"R615-R624","source":"Crossref","is-referenced-by-count":11,"title":["Differential role of adrenoceptors in control of plasma glucose and fatty acids in carp,<i>Cyprinus carpio<\/i>(L.)"],"prefix":"10.1152","volume":"281","author":[{"given":"Guido","family":"Van Den Thillart","sequence":"first","affiliation":[{"name":"Institute of Evolutionary and Ecological Sciences, Van der Klaauw Laboratories, 2300 RA 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