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Plasma ACTH and corticosterone levels remained significantly higher after the diurnal peak for several hours in WKY rats relative to Wistar rats. Also, plasma levels of thyroid-stimulating hormone were significantly higher in WKY relative to Wistar rats across the 24-h period, despite normal or slightly higher levels of 3,5,3\u2032-triiodothyronine. In addition, under constant darkness conditions, WKY rats exhibited a shorter free running period and a decreased response to a phase-delaying light pulse compared with Wistar rats. In several ways these results are similar to those seen in other animal models of depression as well as in depressed humans, suggesting that the WKY rat could be used to investigate the genetic basis for these abnormalities.<\/jats:p>","DOI":"10.1152\/ajpregu.2001.281.3.r786","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T12:38:13Z","timestamp":1513859893000},"page":"R786-R794","source":"Crossref","is-referenced-by-count":113,"title":["Altered hormone levels and circadian rhythm of activity in the WKY rat, a putative animal model of depression"],"prefix":"10.1152","volume":"281","author":[{"given":"Leah C.","family":"Solberg","sequence":"first","affiliation":[{"name":"Departments of Psychiatry and Behavioral Sciences and"},{"name":"Neurobiology and Physiology, Northwestern University, Chicago, Illinois 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan 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