{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:35:20Z","timestamp":1759588520231},"reference-count":30,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2001,9,1]]},"abstract":"<jats:p>The present studies test the hypothesis that contraction to EGF is dependent on mineralocorticoids and\/or an elevation in systolic blood pressure (SBP). Endothelium-denuded thoracic aortas from sham normotensive, N<jats:sup>\u03c9<\/jats:sup>-nitro-l-arginine (l-NNA) hypertensive, Wistar-Kyoto (WKY), and spontaneously hypertensive rats (SHR) were used in isolated tissue-bath experiments. Maximal contraction to epidermal growth factor [EGF; percentage of phenylephrine (PE; 10 umol\/l)-induced contraction] was greater in strips from l-NNA (32 \u00b1 5%) and SHR (53 \u00b1 8%) rats compared with sham and WKY rats (17 \u00b1 1 and 12 \u00b1 4%, respectively). Wistar-Furth rats became only mildly hypertensive when given DOCA salt (134 \u00b1 6 mmHg) compared with Wistar rats (176 \u00b1 9 mmHg), but aortas from both strains had a similarly enhanced contraction to EGF (\u223c9 times the maximal contraction of sham aorta). Furthermore, in vitro incubation of aortas from Wistar and Wistar-Furth rats with aldosterone (10 nmol\/l) increased EGF-receptor mRNA expression by &gt;50%. These data indicate that arterial contraction to EGF may occur independent of hypertension and be stimulated by mineralocorticoids.<\/jats:p>","DOI":"10.1152\/ajpregu.2001.281.3.r878","type":"journal-article","created":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T12:38:13Z","timestamp":1513859893000},"page":"R878-R886","source":"Crossref","is-referenced-by-count":24,"title":["Mineralocorticoids upregulate arterial contraction to epidermal growth factor"],"prefix":"10.1152","volume":"281","author":[{"given":"Jennifer A.","family":"Florian","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824 \u2013 1317; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Dorrance","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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