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A\/A produced a decrease of intercontraction intervals in both female and male animals, and the extent of the decrease in male mice was much less than in female mice [19 \u00b1 5% ( P = 0.03) vs. 65 \u00b1 5% ( P = 0.03); n = 6 for each], exhibiting a marked difference between the two groups in response to acid irritation of the LUT ( P = 0.002). A\/A reduced maximal voiding pressure (MVP) (19 \u00b1 4%, P = 0.03) but had no effect on pressure threshold for inducing voiding contraction (PT) ( P = 0.56) in females, whereas A\/A did not change MVP ( P = 1.00) but increased PT (16 \u00b1 4%, P = 0.03) in males. A\/A decreased bladder compliances of female and male mice in a similar fashion (44 \u00b1 10% vs. 24 \u00b1 7%, P = 0.03 for each). In male mice, A\/A produced persistent dribbling of fluid after voiding contraction phase, which was virtually not seen in females. The present study demonstrates the differences between female and male mice in response to noxious stimulation in the LUT: the female bladder is more sensitive to the acid irritation, while the male urethra is more irritable to the noxious stimulus. 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