{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:10:07Z","timestamp":1790615407456,"version":"4.1.0"},"reference-count":49,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p> Hyperthermia-induced hyperventilation has been proposed to be a human thermolytic thermoregulatory response and to contribute to the disproportionate increase in exercise ventilation (V\u0307e) relative to metabolic needs during high-intensity exercise. In this study it was hypothesized that V\u0307e would adapt similar to human eccrine sweating (\u0116<jats:sub>SW<\/jats:sub>) following a passive heat acclimation (HA). All participants performed an incremental exercise test on a cycle ergometer from rest to exhaustion before and after a 10-day passive exposure for 2 h\/day to either 50\u00b0C and 20% relative humidity (RH) ( n = 8, Acclimation group) or 24\u00b0C and 32% RH ( n = 4, Control group). Attainment of HA was confirmed by a significant decrease ( P = 0.025) of the esophageal temperature (T<jats:sub>es<\/jats:sub>) threshold for the onset of \u0116<jats:sub>SW<\/jats:sub> and a significantly elevated \u0116<jats:sub>SW<\/jats:sub> ( P \u2264 0.040) during the post-HA exercise tests. HA also gave a significant decrease in resting T<jats:sub>es<\/jats:sub> ( P = 0.006) and a significant increase in plasma volume ( P = 0.005). Ventilatory adaptations during exercise tests following HA included significantly decreased T<jats:sub>es<\/jats:sub> thresholds ( P \u2264 0.005) for the onset of increases in the ventilatory equivalents for O<jats:sub>2<\/jats:sub> (V\u0307e\/V\u0307o<jats:sub>2<\/jats:sub>) and CO<jats:sub>2<\/jats:sub> (V\u0307e\/V\u0307co<jats:sub>2<\/jats:sub>) and a significantly increased V\u0307e ( P \u2264 0.017) at all levels of T<jats:sub>es<\/jats:sub>. Elevated V\u0307e was a function of a significantly greater tidal volume ( P = 0.003) at lower T<jats:sub>es<\/jats:sub> and of breathing frequency ( P \u2264 0.005) at higher T<jats:sub>es<\/jats:sub>. Following HA, the ventilatory threshold was uninfluenced and the relationships between V\u0307o<jats:sub>2<\/jats:sub> and either V\u0307e\/V\u0307o<jats:sub>2<\/jats:sub> or V\u0307e\/V\u0307co<jats:sub>2<\/jats:sub> did not explain the resulting hyperventilation. In conclusion, the results support that exercise V\u0307e following passive HA responds similarly to \u0116<jats:sub>SW<\/jats:sub>, and the mechanism accounting for this adaptation is independent of changes of the ventilatory threshold or relationships between V\u0307o<jats:sub>2<\/jats:sub> with each of V\u0307e\/V\u0307o<jats:sub>2<\/jats:sub> and V\u0307e\/V\u0307co<jats:sub>2<\/jats:sub>. <\/jats:p>","DOI":"10.1152\/ajpregu.90672.2008","type":"journal-article","created":{"date-parts":[[2009,6,4]],"date-time":"2009-06-04T01:54:59Z","timestamp":1244080499000},"page":"R605-R614","source":"Crossref","is-referenced-by-count":51,"title":["Adaptation of exercise ventilation during an actively-induced hyperthermia following passive heat acclimation"],"prefix":"10.1152","volume":"297","author":[{"given":"Andrew E.","family":"Beaudin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam E.","family":"Clegg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00376772"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.2165\/00007256-199723030-00004"},{"key":"R3","unstructured":"Armstrong LE, Stoppani J. 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