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The ARNA response to reflex increases in ERSNA was enhanced in high (HNa)- vs. low-sodium (LNa) diet rats, 7,560 \u00b1 1,470 vs. 900 \u00b1 390%\u00b7s. The norepinephrine (NE) concentration required to increase PGE<jats:sub>2<\/jats:sub> and substance P release from isolated renal pelvises was 10 pM in HNa and 6,250 pM in LNa diet rats. In HNa diet pelvises 10 pM NE increased PGE<jats:sub>2<\/jats:sub> release from 67 \u00b1 6 to 150 \u00b1 13 pg\/min and substance P release from 6.7 \u00b1 0.8 to 12.3 \u00b1 1.8 pg\/min. In LNa diet pelvises 6,250 pM NE increased PGE<jats:sub>2<\/jats:sub> release from 64 \u00b1 5 to 129 \u00b1 22 pg\/min and substance P release from 4.5 \u00b1 0.4 to 6.6 \u00b1 0.7 pg\/min. In the renal pelvic wall, ETB-R are present on unmyelinated Schwann cells close to the afferent nerves and ETA-R on smooth muscle cells. ETA-receptor (R) protein expression in the renal pelvic wall is increased in LNa diet. In HNa diet, renal pelvic administration of the ETB-R antagonist BQ788 reduced ERSNA-induced increases in ARNA and NE-induced release of PGE<jats:sub>2<\/jats:sub> and substance P. In LNa diet, the ETA-R antagonist BQ123 enhanced ERSNA-induced increases in ARNA and NE-induced release of substance P without altering PGE<jats:sub>2<\/jats:sub> release. In conclusion, activation of ETB-R and ETA-R contributes to the enhanced and suppressed interaction between ERSNA and ARNA in conditions of HNa and LNa diet, respectively, suggesting a role for ET in the renal control of ERSNA that is dependent on dietary sodium. <\/jats:p>","DOI":"10.1152\/ajpregu.91029.2008","type":"journal-article","created":{"date-parts":[[2009,5,28]],"date-time":"2009-05-28T02:15:30Z","timestamp":1243476930000},"page":"R337-R351","source":"Crossref","is-referenced-by-count":30,"title":["Dietary sodium modulates the interaction between efferent renal sympathetic nerve activity and afferent renal nerve activity: role of endothelin"],"prefix":"10.1152","volume":"297","author":[{"given":"Ulla C.","family":"Kopp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olaf","family":"Grisk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Z.","family":"Cicha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Steinbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Schl\u00fcter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"M\u00e4hler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"H\u00f6kfelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200421064"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1990.259.3.F503"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90156-2"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.08.004"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90298.2008"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91072-7"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8609"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117620"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1038\/35058528"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Hori S, Komatsu Y, Shigemoto R, Mizuno N, Nakanishi S. 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