{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:05:29Z","timestamp":1770325529712,"version":"3.49.0"},"reference-count":56,"publisher":"American Physiological Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2013,10,15]]},"abstract":"<jats:p>1, 25-Dihydroxycholechalciferol (calcitriol) and 19-nor-1, 25-dihydroxyvitamin D<jats:sub>2<\/jats:sub>(paricalcitol) are vitamin D receptor (VDR) agonists. Previous data suggest VDR agonists may actually increase renin-angiotensin activity, and this has always been assumed to be mediated by hypercalcemia. We hypothesized that calcitriol and paricalcitol would increase plasma renin activity (PRA) independently of plasma Ca<jats:sup>2+<\/jats:sup>via hypercalciuria-mediated polyuria, hypovolemia, and subsequent increased \u03b2-adrenergic sympathetic activity. We found that both calcitriol and paricalcitol increased PRA threefold ( P &lt; 0.01). Calcitriol caused hypercalcemia, but paricalcitol did not. Both calcitriol and paricalcitol caused hypercalciuria (9- and 7-fold vs. control, P &lt; 0.01) and polyuria (increasing 2.6- and 2.2-fold vs. control, P &lt; 0.01). Paricalcitol increased renal calcium-sensing receptor (CaSR) expression, suggesting a potential cause of paricalcitol-mediated hypercalciuria and polyuria. Volume replacement completely normalized calcitriol-stimulated PRA and lowered plasma epinephrine by 43% ( P &lt; 0.05). \u03b2-Adrenergic blockade also normalized calcitriol-stimulated PRA. Cyclooxygenase-2 inhibition had no effect on calcitriol-stimulated PRA. Our data demonstrate that vitamin D increases PRA independently of plasma Ca<jats:sup>2+<\/jats:sup>via hypercalciuria, polyuria, hypovolemia, and increased \u03b2-adrenergic activity.<\/jats:p>","DOI":"10.1152\/ajprenal.00010.2013","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T06:22:30Z","timestamp":1375942950000},"page":"F1109-F1117","source":"Crossref","is-referenced-by-count":11,"title":["Vitamin D increases plasma renin activity independently of plasma Ca<sup>2+<\/sup>via hypovolemia and \u03b2-adrenergic activity"],"prefix":"10.1152","volume":"305","author":[{"given":"Douglas K.","family":"Atchison","sequence":"first","affiliation":[{"name":"Hypertension and Vascular Research Division, Department of Internal Medicine, Henry Ford Health System, Detroit, Michigan; and"},{"name":"Department of Physiology, Wayne State University School of Medicine, Detroit, 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