{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:36:25Z","timestamp":1788561385486,"version":"build-2803163510"},"reference-count":20,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki (Polish National Science Centre)","doi-asserted-by":"publisher","award":["UMO-2013\/09\/B\/NZ5\/02489"],"award-info":[{"award-number":["UMO-2013\/09\/B\/NZ5\/02489"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2018,9,1]]},"abstract":"<jats:p> Experimental data have shown increased plasma levels of marinobufagenin in kidney failure. In this case-controlled retrospective analysis, we evaluated plasma marinobufagenin immunoreactivity in hemodialysis patients compared with subjects with normal kidney function. Sixty-eight adult hemodialysis patients with chronic kidney disease (34 females and 34 males) as well as 68 age-, gender-, and blood pressure-matched subjects without chronic kidney disease were enrolled. Patients on stable hemodialysis regimen for at least 3 mo before the study were included. Exclusion criteria were: age &lt;18 yr, severe liver or heart insufficiency, and overhydration. Subjects without chronic kidney disease must have had an estimated glomerular filtration rate \u226560 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b71.72 m<jats:sup>\u22122<\/jats:sup> according to the Modification of Diet in Renal Disease formula. Plasma marinobufagenin immunoreactivity was significantly ( P &lt; 0.001) higher in hemodialysis patients (1.66\u2009\u00b1\u20091.13 nmol\/l) compared with subjects with normal kidney function (0.46\u2009\u00b1\u20090.23). In hemodialysis patients, plasma marinobufagenin immunoreactivity was higher in men compared with women. A significant positive correlation has been found between plasma marinobufagenin immunoreactivity and serum NT-proBNP, NT-proANP, or aldosterone concentrations in all analyzed subjects. In hemodialyzed patients with plasma marinobufagenin immunoreactivity above median value 5-yr, all-cause mortality was higher compared with those with plasma marinobufagenin concentration below median. We have shown that plasma marinobufagenin immunoreactivity is increased in patients with end-stage kidney failure treated with hemodialysis parallel to the increase in serum NT-proBNP, NT-proANP, and aldosterone concentrations. Higher marinobufagenin immunoreactivity has been associated with worse survival in hemodialyzed patients. <\/jats:p>","DOI":"10.1152\/ajprenal.00046.2018","type":"journal-article","created":{"date-parts":[[2018,7,25]],"date-time":"2018-07-25T07:45:11Z","timestamp":1532504711000},"page":"F637-F643","source":"Crossref","is-referenced-by-count":12,"title":["Plasma marinobufagenin immunoreactivity in patients with chronic kidney disease: a case control study"],"prefix":"10.1152","volume":"315","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8371-0195","authenticated-orcid":false,"given":"Grzegorz","family":"Piecha","sequence":"first","affiliation":[{"name":"Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Kujawa-Szewieczek","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Kuczera","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Skiba","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewelina","family":"Sikora-Grabka","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Wi\u0119cek","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.154815"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00782.2007"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1124\/pr.108.000711"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.1994.1098"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-017-1698-4"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000252409.36927.05"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e328312c86a"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004030203"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpt169"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2012.17"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004106"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2014.12.005"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001976"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq772"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30389-0"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.5604\/17322693.1197486"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.04.011"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01883.x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043545"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.018325"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00046.2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,22]],"date-time":"2019-09-22T07:48:16Z","timestamp":1569138496000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00046.2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,1]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9,1]]}},"alternative-id":["10.1152\/ajprenal.00046.2018"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00046.2018","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,1]]}}}