{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:16:42Z","timestamp":1762899402268,"version":"3.37.3"},"reference-count":29,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare (Ministry of Health, Welfare and Family Affairs)","doi-asserted-by":"publisher","award":["HI15C0972"],"award-info":[{"award-number":["HI15C0972"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2017,8,1]]},"abstract":"<jats:p> Partial nephrectomy aims to maintain renal function by nephron sparing; however, functional changes in the contralateral kidney remain unknown. We evaluate the functional change in the contralateral kidney using a diethylene triamine penta-acetic acid (DTPA) renal scan and determine factors predicting contralateral kidney function after partial nephrectomy. A total of 699 patients underwent partial nephrectomy, with a DTPA scan before and after surgery to assess the separate function of each kidney. Patients were divided into three groups according to initial contralateral glomerular filtration rate (GFR; group 1: &lt;30 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b71.73 m<jats:sup>\u22122<\/jats:sup>, group 2: 30\u201345 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b71.73 m<jats:sup>\u22122<\/jats:sup>, and group 3: \u226545 ml\u00b7min<jats:sup>\u22121<\/jats:sup>\u00b71.73 m<jats:sup>\u22122<\/jats:sup>). Multiple-regression analysis was used to identify the factors associated with increased GFR of the contralateral kidney over a 4-yr postoperative period. Patients in group 1 had a higher mean age and hypertension history, worse American Society of Anesthesiologists score, and larger tumor size than in the other two groups. The ipsilateral GFR changes at 4 yr after partial nephrectomy were \u221218.9, \u22123.6, and 3.9% in groups 1, 2, and 3, respectively, whereas the contralateral GFR changes were 10.8, 25.7, and 38.8%. Age [\u03b2: \u22120.105, 95% confidence interval (CI): \u22120.213; \u22120.011, P &lt; 0.05] and preoperative contralateral GFR (\u03b2: \u22120.256, 95% CI: \u22120.332; \u22120.050, P &lt; 0.01) were significant predictive factors for increased GFR of the contralateral kidney after 4 yr. The contralateral kidney compensated for the functional loss of the ipsilateral kidney. The increase of GFR in contralateral kidney is more prominent in younger patients with decreased contralateral renal function. <\/jats:p>","DOI":"10.1152\/ajprenal.00058.2017","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T20:25:34Z","timestamp":1492028734000},"page":"F192-F198","source":"Crossref","is-referenced-by-count":8,"title":["Adaptive functional change of the contralateral kidney after partial nephrectomy"],"prefix":"10.1152","volume":"313","author":[{"given":"Se Young","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sangjun","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 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