{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:29:18Z","timestamp":1778275758988,"version":"3.51.4"},"reference-count":22,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs (VA)","doi-asserted-by":"publisher","award":["VA Merit"],"award-info":[{"award-number":["VA Merit"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["P30-DK-079337"],"award-info":[{"award-number":["P30-DK-079337"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2019,2,1]]},"abstract":"<jats:p> Tubuloglomerular feedback (TGF) responses become anomalous in rats fed high-NaCl diet after subtotal nephrectomy (STN), such that stimulating TGF causes single nephron GFR (SNGFR) to increase rather than decrease. Micropuncture experiments were performed to determine whether this anomaly results from heightened nitric oxide response to distal delivery, which is a known mechanism for resetting TGF, or from connecting tubule TGF (cTGF), which is a novel amiloride-inhibitable system for offsetting TGF responses. Micropuncture was done in Wistar Froemter rats fed high-NaCl diet (HS) for 8\u201310 days after STN or sham nephrectomy. TGF was manipulated by orthograde microperfusion of Henle\u2019s loop with artificial tubular fluid with or without NOS inhibitor, LNMMA, or the cell-impermeant amiloride analog, benzamil. SNGFR was measured by inulin clearance in tubular fluid collections from the late proximal tubule. TGF responses were quantified as the increase in SNGFR that occurred when the perfusion rate was reduced from 50 to 8 nl\/min in STN or 40 to 8 nl\/min in sham animals. The baseline TGF response was anomalous in STN HS (\u22124\u2009\u00b1\u20093 vs 14\u2009\u00b1\u20093 nl\/min, P &lt; 0.001). TGF response was normalized by perfusing STN nephron with LNMMA (14\u2009\u00b1\u20093 nl\/min, P &lt; 0.005 for ANOVA cross term) but not with benzamil (\u22123\u2009\u00b1\u20094 nl\/min, P = 0.4 for ANOVA cross term). Anomalous TGF occurs in STN HS due to heightened effect of tubular flow on nitric oxide signaling, which increases to the point of overriding the normal TGF response. There is no role for cTGF in this phenomenon. <\/jats:p>","DOI":"10.1152\/ajprenal.00066.2018","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T10:33:08Z","timestamp":1540981988000},"page":"F223-F230","source":"Crossref","is-referenced-by-count":7,"title":["Nitric oxide mediates anomalous tubuloglomerular feedback in rats fed high-NaCl diet after subtotal nephrectomy"],"prefix":"10.1152","volume":"316","author":[{"given":"Scott C.","family":"Thomson","sequence":"first","affiliation":[{"name":"Division of Nephrology-Hypertension, VA San Diego Healthcare System and University of California, San Diego School of Medicine, La Jolla, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1996.271.4.F861"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1991.261.5.F880"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00282.x"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015050515"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.153692"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02040"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002190"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000500521.58587.86"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021014-071829"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116244"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2011020130"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90722.2008"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00431.2013"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.09584"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8761"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1993.264.6.F930"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1159\/000069766"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-004-1239-8"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1995.269.6.F892"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00673.2011"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00403.2010"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00173.2015"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00066.2018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T10:20:14Z","timestamp":1569320414000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00066.2018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,1]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2,1]]}},"alternative-id":["10.1152\/ajprenal.00066.2018"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00066.2018","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,1]]}}}