{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:09:26Z","timestamp":1788206966379,"version":"build-2803163510"},"reference-count":44,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>\n                    Loop diuretics like furosemide have been shown to cause renal vasodilatation in dogs and humans, an effect thought to result from both a direct vascular dilator effect and from inhibition of tubuloglomerular feedback. In isolated perfused afferent arterioles preconstricted with angiotensin II or N\n                    <jats:sup>G<\/jats:sup>\n                    -nitro-l-arginine methyl ester, furosemide caused a dose-dependent increase of vascular diameter, but it was without effect in vessels from NKCC1\u2212\/\u2212 mice suggesting that inhibition of NKCC1 mediates dilatation in afferent arterioles. In the intact kidney, however, furosemide (2 mg\/kg iv) caused a 50.5 \u00b1 3% reduction of total renal blood flow (RBF) and a 27% reduction of superficial blood flow (SBF) accompanied by a marked and immediate increase of tubular pressure and volume. At 10 mg\/kg, furosemide reduced RBF by 60.4 \u00b1 2%. Similarly, NKCC1\u2212\/\u2212 mice responded to furosemide with a 45.4% decrease of RBF and a 29% decrease of SBF. Decreases in RBF and SBF and increases of tubular pressure by furosemide were ameliorated by renal decapsulation. In addition, pretreatment with candesartan (2 mg\/kg) or indomethacin (5 mg\/kg) attenuated the reduction of RBF and peak urine flows caused by furosemide. Our data indicate that furosemide, despite its direct vasodilator potential in isolated afferent arterioles, causes a marked increase in flow resistance of the vascular bed of the intact mouse kidney. We suggest that generation of angiotensin II and\/or a vasoconstrictor prostaglandin combined with compression of peritubular capillaries by the expanding tubular compartment are responsible for the reduction of RBF in vivo.\n                  <\/jats:p>","DOI":"10.1152\/ajprenal.00073.2007","type":"journal-article","created":{"date-parts":[[2007,5,9]],"date-time":"2007-05-09T20:43:59Z","timestamp":1178743439000},"page":"F279-F287","source":"Crossref","is-referenced-by-count":60,"title":["Vasodilatation of afferent arterioles and paradoxical increase of renal vascular resistance by furosemide in mice"],"prefix":"10.1152","volume":"293","author":[{"given":"Mona","family":"Oppermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille B.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayo","family":"Castrop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Schnermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1999.276.6.C1383"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1985.152"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00455.2004"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10318"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(79)90217-6"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-445X.2000.02064.x"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1113\/eph8602219"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)00134-4"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.38.26946"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1980.158"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.62.1.515"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-001-0521-y"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000086474.80845.25"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-004-1330-1"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1007\/BF00169143"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1997.272.3.F389"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.094888"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00988.x"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00521.2005"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1992.263.6.R1182"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1986.250.2.F282"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205627200"},{"key":"R23","unstructured":"Miyanoshita A\n                      , Terada M, Endou H.\n                      Furosemide directly stimulates prostaglandin E\n                      2\n                      production in the thick ascending limb of Henle's loop.\n                      J Pharmacol Exp Ther\n                      251\n                      : 1155\u20131159, 1989."},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(81)90092-7"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1978.235.4.F352"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.2.753"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114373"},{"key":"R28","unstructured":"Okusa MD\n                      , Ellison DH.\n                      Physiology and pathophysiology of diuretic agents. In:\n                      The Kidney. Physiology and Pathophysiology\n                      , edited by Seldin DW and Giebisch G. Philadelphia: Lippincott Williams & Wilkins, 2000, p. 2877\u20132922."},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.26.15496"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1979.236.5.F494"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00533.2006"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00028.2001"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703693"},{"key":"R34","unstructured":"Puschett JB\n                      , Goldberg M.\n                      The acute effects of furosemide on acid and electrolyte excretion in man.\n                      J Lab Clin Med\n                      71\n                      : 666\u2013677, 1968."},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00346.2005"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.090091297"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00343.2006"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(77)90326-0"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1991.261.2.F273"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107721"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00420.2002"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1995.268.4.L642"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008664200"},{"key":"R44","doi-asserted-by":"crossref","unstructured":"Yoshida M\n                      , Suzuki-Kusaba M, Satoh S.\n                      Participation of the prostaglandin system in furosemide-induced changes of renal function in anesthetized rats.\n                      Renal Physiol\n                      10\n                      : 25\u201332, 1987.","DOI":"10.1159\/000173110"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00073.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:37:10Z","timestamp":1567967830000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00073.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["10.1152\/ajprenal.00073.2007"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00073.2007","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1086075.539041","asserted-by":"object"}]},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}