{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T18:50:27Z","timestamp":1789325427969,"version":"build-2803163510"},"reference-count":196,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL131834"],"award-info":[{"award-number":["R01HL131834"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["R03AG075396"],"award-info":[{"award-number":["R03AG075396"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:p> The growing prevalence of hypertension, heart disease, diabetes, and obesity along with an aging population is leading to a higher incidence of renal diseases in society. Chronic kidney disease (CKD) is characterized mainly by persistent inflammation, fibrosis, and gradual loss of renal function leading to renal failure. Sex is a known contributor to the differences in incidence and progression of CKD. Epigenetic programming is an essential regulator of renal physiology and is critically involved in the pathophysiology of renal injury and fibrosis. Epigenetic signaling integrates intrinsic and extrinsic signals onto the genome, and various environmental and hormonal stimuli, including sex hormones, which regulate gene expression and downstream cellular responses. The most extensively studied epigenetic alterations that play a critical role in renal damage include histone modifications and DNA methylation. Notably, these epigenetic alterations are reversible, making them candidates for potential therapeutic targets for the treatment of renal diseases. Here, we will summarize the current knowledge on sex differences in epigenetic modulation of renal fibrosis and inflammation and highlight some possible epigenetic therapeutic strategies for CKD treatment. <\/jats:p>","DOI":"10.1152\/ajprenal.00091.2023","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T08:00:35Z","timestamp":1691654435000},"page":"F578-F594","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Sex-specific epigenetic programming in renal fibrosis and inflammation"],"prefix":"10.1152","volume":"325","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5989-1878","authenticated-orcid":false,"given":"Prerna","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine, Tulane University, New Orleans, Louisiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heddwen L.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Tulane University, New Orleans, Louisiana, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.112"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.02.005"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063127"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nature02625"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2014.04.007"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00487.2016"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI158446"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0039"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113354"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2014.11.006"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/349038a0"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/35047580"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.20.2225"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2987"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000463"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/nep.13806"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00147-002-0449-2"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2013.05.004"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015511"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.02.034"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2011.149"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034227"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0000000000000839"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2931049"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.760308"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7242384"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1126\/science.1191078"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2905"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-8104-5_1"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018762"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.11"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2018.08.014"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000602"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acc.2020.09.005"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20180061"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.76.052705.162114"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2017.11.004"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a018713"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4286"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2145"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.5b00841"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00313.2017"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2020.194609"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112839"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.114.13.2363"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb05964.x"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210599"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.10.028"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017111218"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186686"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2485"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10091356"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.11.006"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00431.2011"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2016.08.001"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfp730"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00523.2012"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20071554"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.4161\/15592294.2014.990780"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2017.1370173"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00400.2009"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00073.2015"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1124\/mol.114.092221"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2016.03.016"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710964114"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014111067"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.248278"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00102.2014"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1042\/CS20210470"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.695237"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-00631-9"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201903254R"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11031-0"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1172\/JCI124030"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00086.2009"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00166.2017"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0054001"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13061"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0167340"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00261.2020"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1038\/srep33676"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00235"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-017-0140-z"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00015.2013"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16153"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy009"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-018-0103-6"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5985903"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2010.02.003"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00282.2009"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21175966"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-017-0630-6"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13106"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201801067RR"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00405.2020"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00546.2016"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2015.04.006"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800237R"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22180-5"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.11.006"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt012"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2012.03.009"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01393"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.4161\/epi.26793"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.08.006"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2009.04.012"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1101\/gr.103200.109"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1159\/000517073"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.12.012"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-00542-2"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-20-0404"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25538"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-022-01305-8"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.3390\/ph15020123"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00307"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015040457"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00061.2009"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2016.59"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010060633"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101914200"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1101\/gad.989402"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.291"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160595"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802800200"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00697.2012"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196844"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014090850"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1008796"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-017-0657-7"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.207761"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/654148"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060549"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.13795"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.11849"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101566R"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1177\/09603271211038743"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-021-00771-z"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.7150\/thno.48679"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1967"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2016.00093"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.02.015"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.17.4905"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0159-6"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020381"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00638.2014"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1038\/366362a0"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0114-y"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3988"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2006.08.006"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq154"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8817.2004.00081.x"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2011.02147.x"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2010.06.017"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204341"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.4161\/epi.27161"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-021-01064-y"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.13716"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01297-7"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190280"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.4161\/epi.6.1.13362"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2013-14-10-r108"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018070736"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2017.03.002"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.03.013"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-04577-3"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft537"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2020.1819666"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1159\/000339437"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1186\/1755-8794-3-33"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2012-0465"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2135"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.01.010"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.21767\/2472-1158.100011"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2014.11.005"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.07.042"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1159\/000477507"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214045"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a039099"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23886"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.4161\/epi.4.1.7288"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910578107"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-0193"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600352"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90419-q"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2013.04.026"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113548"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1002\/bies.202200148"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1016\/s0008-6363(99)00153-4"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2006.10.004"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-020-02761-y"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgp308"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2013.07.019"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-019-01759-z"},{"key":"B194","first-page":"2279","volume":"55","author":"Ferguson AT","year":"1995","journal-title":"Cancer Res"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2014.12.015"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-019-01221-3"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00091.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T13:32:24Z","timestamp":1696944744000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajprenal.00091.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":196,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,11,1]]}},"alternative-id":["10.1152\/ajprenal.00091.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00091.2023","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,1]]},"assertion":[{"value":"2023-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-18","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}