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It allows the kidneys to increase body water retention predominantly by increasing the cell surface expression of aquaporin water channels in the collecting duct alongside increasing the osmotic driving forces for water reabsorption. The antinatriuretic effects of AVP are mediated by the regulation of sodium transport throughout the distal nephron, from the thick ascending limb through to the collecting duct, which in turn partially facilitates osmotic movement of water. In this review, we will discuss the regulatory role of AVP in sodium transport and summarize the effects of AVP on various molecular targets, including the sodium-potassium-chloride cotransporter NKCC2, the thiazide-sensitive sodium-chloride cotransporter NCC, and the epithelial sodium channel ENaC.<\/jats:p>","DOI":"10.1152\/ajprenal.00093.2015","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T07:07:45Z","timestamp":1433401665000},"page":"F280-F299","source":"Crossref","is-referenced-by-count":76,"title":["Vasopressin regulation of sodium transport in the distal nephron and collecting duct"],"prefix":"10.1152","volume":"309","author":[{"given":"M. L. A.","family":"Kortenoeven","sequence":"first","affiliation":[{"name":"Department of Biomedicine and Center for Interactions of Proteins in Epithelial Transport (InterPrET), Aarhus University, Aarhus, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. 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