{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T08:32:07Z","timestamp":1793781127257,"version":"4.6.1"},"reference-count":25,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2005,10]]},"abstract":"<jats:p> The idea that Na<jats:sup>+<\/jats:sup> retention inevitably leads to water retention is compelling; however, were Na<jats:sup>+<\/jats:sup> accumulation in part osmotically inactive, regulatory alternatives would be available. We speculated that in DOCA-salt rats Na<jats:sup>+<\/jats:sup> accumulation is excessive relative to water. Forty female Sprague-Dawley rats were divided into four subgroups. Groups 1 and 2 (controls) received tap water or 1% saline (salt) for 5 wk. Groups 3 and 4 received subcutaneous DOCA pellets and tap water or salt. Na<jats:sup>+<\/jats:sup>, K<jats:sup>+<\/jats:sup>, and water were measured in skin, bone, muscle, and total body by desiccation and consecutive dry ashing. DOCA-salt led to total body Na<jats:sup>+<\/jats:sup> excess (0.255 \u00b1 0.022 vs. 0.170 \u00b1 0.010 mmol\/g dry wt; P &lt; 0.001), whereas water retention was only moderate (0.685 \u00b1 0.119 vs. 0.648 \u00b1 0.130 ml\/g wet wt; P &lt; 0.001). Muscle Na<jats:sup>+<\/jats:sup> retention (0.220 \u00b1 0.029 vs. 0.145 \u00b1 0.021 mmol\/g dry wt; P &lt; 0.01) in DOCA-salt was compensated by muscle K<jats:sup>+<\/jats:sup> loss, indicating osmotically neutral Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup> exchange. Skin Na<jats:sup>+<\/jats:sup> retention (0.267 \u00b1 0.049 vs. 0.152 \u00b1 0.014 mmol\/g dry wt; P &lt; 0.001) in DOCA-salt rats was not balanced by K<jats:sup>+<\/jats:sup> loss, indicating osmotically inactive skin Na<jats:sup>+<\/jats:sup> storage. We conclude that DOCA-salt leads to tissue Na<jats:sup>+<\/jats:sup> excess relative to water. The relative Na<jats:sup>+<\/jats:sup> excess is achieved by two distinct mechanisms, namely, osmotically inactive Na<jats:sup>+<\/jats:sup> storage and osmotically neutral Na<jats:sup>+<\/jats:sup> retention balanced by K<jats:sup>+<\/jats:sup> loss. This \u201cinternal Na<jats:sup>+<\/jats:sup> escape\u201d allows the maintenance of volume homeostasis despite increased total body Na<jats:sup>+<\/jats:sup>. <\/jats:p>","DOI":"10.1152\/ajprenal.00096.2005","type":"journal-article","created":{"date-parts":[[2005,5,25]],"date-time":"2005-05-25T02:48:50Z","timestamp":1116989330000},"page":"F793-F802","source":"Crossref","is-referenced-by-count":109,"title":["Internal sodium balance in DOCA-salt rats: a body composition study"],"prefix":"10.1152","volume":"289","author":[{"given":"Jens","family":"Titze","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Schafflhuber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dietsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl H.","family":"Schwind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedrich C.","family":"Luft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Uwe","family":"Eckardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl F.","family":"Hilgers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103168"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102959"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-7061(98)00031-4"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103330"},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Friedman SM, McIndoe RA, and Tanaka M. 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