{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T07:05:47Z","timestamp":1779347147914,"version":"3.51.4"},"reference-count":56,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>Cytokines are upregulated in a variety of inflammatory conditions and cytokine\/receptor interactions can activate JAK-STAT signaling. Previous studies demonstrated upregulation of numerous cytokines in the urinary bladder following cyclophosphamide (CYP)-induced cystitis. The role of JAK-STAT signaling in urinary bladder inflammation and referred somatic sensitivity has not been addressed. The contribution of JAK-STAT signaling pathways in CYP-induced bladder hyperreflexia and referred somatic hypersensitivity was determined in CYP-treated rats using a JAK2 inhibitor, AG490. Acute (4 h; 150 mg\/kg ip), intermediate (48 h; 150 mg\/kg ip), or chronic (75 mg\/kg ip, once every 3 days for 10 days) cystitis was induced in adult, female Wistar rats with CYP treatment. Phosphorylation status of STAT-3 was increased in urinary bladder after CYP-induced cystitis (4 h, 48 h, chronic). Blockade of JAK2 with AG490 (5\u201315 mg\/kg ip or intravesical) significantly ( P \u2264 0.05) reduced bladder hyperreflexia and hind paw sensitivity in CYP-treated rats. These studies demonstrate a potential role for JAK-STAT signaling pathways in bladder hyperreflexia and referred pain induced by CYP-induced bladder inflammation.<\/jats:p>","DOI":"10.1152\/ajprenal.00110.2009","type":"journal-article","created":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:55:20Z","timestamp":1248310520000},"page":"F1038-F1044","source":"Crossref","is-referenced-by-count":31,"title":["Involvement of JAK-STAT signaling\/function after cyclophosphamide-induced bladder inflammation in female rats"],"prefix":"10.1152","volume":"297","author":[{"given":"Bopaiah P.","family":"Cheppudira","sequence":"first","affiliation":[{"name":"Departments of 1 Neurology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice M.","family":"Girard","sequence":"additional","affiliation":[{"name":"Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan E.","family":"Malley","sequence":"additional","affiliation":[{"name":"Departments of 1 Neurology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbey","family":"Dattilio","sequence":"additional","affiliation":[{"name":"Departments of 1 Neurology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin C.","family":"Schutz","sequence":"additional","affiliation":[{"name":"Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"May","sequence":"additional","affiliation":[{"name":"Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret A.","family":"Vizzard","sequence":"additional","affiliation":[{"name":"Departments of 1 Neurology and"},{"name":"Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington, Vermont"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(01)00024-3"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-02-00859.1999"},{"key":"B3","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1182\/blood.V87.5.1851.1851","volume":"87","author":"Benigni F","year":"1996","journal-title":"Blood"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000145900.22849.1d"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00734.2005"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"B7","author":"Cheppudira B","journal-title":"Soc Neurosci Abstr"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90305.2008"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1996.22164020.x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00857.2006"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03893.x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.06.013"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.6_Supplement.321S"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2008.05566.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36549-7"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/75.2.125"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65517-6"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1515\/REVNEURO.2008.19.4-5.341"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65005-7"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/nau.20178"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/stem.170127"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-008-9084-4"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00728.2007"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)01140-8"},{"key":"B25","first-page":"9","volume-title":"Interstitial Cystitis","author":"Ho N","year":"1997"},{"key":"B26","first-page":"84829","volume":"2006","author":"Hu CP","year":"2006","journal-title":"Med Inf (Lond)"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00465.2002"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000155170.15023.e5"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2004.05.020"},{"key":"B30","first-page":"397","volume":"9","author":"Ivanenkov YA","year":"2008","journal-title":"Drugs"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-02-00478.2002"},{"key":"B32","first-page":"143","author":"Johansson SL","year":"1997","journal-title":"Interstitial Cystitis"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00305.2007"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21627"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90501.2008"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.04.033"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1126\/science.7892601"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/337362a0"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/0160-5402(86)90064-1"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00117.2001"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.08.1108"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1097\/01.aco.0000182567.70798.a7"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2006.01536.x"},{"key":"B44","first-page":"290A","volume":"153","author":"Petrone RL","year":"1995","journal-title":"J Urol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00570.2006"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01131-1"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06137.x"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-008-9100-8"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(00)00115-0"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.278.4.R1027"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7254"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(20000508)420:3<335::AID-CNE5>3.0.CO;2-#"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/0959-4388(94)90053-1"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3023-06.2006"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2006.02.030"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6793-7-9"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00110.2009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T22:31:26Z","timestamp":1590013886000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00110.2009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["10.1152\/ajprenal.00110.2009"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00110.2009","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}