{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:02:48Z","timestamp":1791349368794,"version":"4.3.1"},"reference-count":31,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2004,1]]},"abstract":"\n Glucose uptake is increased in hypertension. Thus we investigated Na\n +<\/jats:sup>\n -glucose cotransporter (SGLT2) activity and expression in proximal tubules from renovascular hypertensive rats. Sham-operated rats, aortic coarctation rats, and aortic coarctation rats treated with either ramipril (2.5 mg\u00b7kg\n -1<\/jats:sup>\n \u00b7day\n -1<\/jats:sup>\n for 21 days) or losartan (10 mg\u00b7kg\n -1<\/jats:sup>\n \u00b7day\n -1<\/jats:sup>\n for 21 days) were used. Na\n +<\/jats:sup>\n -dependent glucose uptake was measured in brush-border membrane vesicles (BBMV). V\n max<\/jats:sub>\n in BBMV from hypertensive rats was greater compared with those from normotensive rats (3 \u00b1 0.2 vs. 1.5 \u00b1 0.1 nmol\u00b7mg protein\n -1<\/jats:sup>\n \u00b7min\n -1<\/jats:sup>\n ) without a change in K\n m<\/jats:sub>\n . Renal immunostaining was greater, and Western blot analysis and RT-PCR showed a higher expression of SGLT2 in hypertensive rats than in normotensive rats (1,029 \u00b1 71 vs. 5,003 \u00b1 292, 199 \u00b1 15 vs. 95 \u00b1 10, and 1.4 \u00b1 0.2 vs. 0.3 \u00b1 0.1 arbitrary units, respectively). In rats treated with either ramipril or losartan, V\n max<\/jats:sub>\n decreased to 2.1 \u00b1 0.3 and 1.8 \u00b1 0.4 nmol\u00b7mg protein\n -1<\/jats:sup>\n \u00b7min\n -1<\/jats:sup>\n , respectively, as well as did the intensity of immunostaining and levels of protein and mRNA. We suggest that in renovascular hypertension, angiotensin II induced SGLT2 via the AT\n 1<\/jats:sub>\n receptor, which was evidenced at both the functional and expression levels, probably contributing to increased absorption of Na\n +<\/jats:sup>\n and thereby to the development or maintenance of hypertension.\n <\/jats:p>","DOI":"10.1152\/ajprenal.00113.2003","type":"journal-article","created":{"date-parts":[[2004,1,30]],"date-time":"2004-01-30T19:56:49Z","timestamp":1075492609000},"page":"F127-F133","source":"Crossref","is-referenced-by-count":63,"title":["Angiotensin II-dependent increased expression of Na\n +<\/sup>\n -glucose cotransporter in hypertension"],"prefix":"10.1152","volume":"286","author":[{"given":"Roc\u00edo","family":"Bautista","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca","family":"Manning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"del Carmen Avila-Casado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Escalante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00587292"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.6.4.445"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"REF4","doi-asserted-by":"crossref","unstructured":"Campbell DJ\n , Duncan AM, Kadis A, and Harrap SB.\n Angiotensin peptides in spontaneously hypertensive and normotensive Donryu rats.\n Hypertension\n 24\n : 928-934, 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