{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:47:29Z","timestamp":1791002849420,"version":"4.1.0"},"reference-count":21,"publisher":"American Physiological Society","issue":"6","funder":[{"name":"NIH","award":["RO1HL133695"],"award-info":[{"award-number":["RO1HL133695"]}]},{"name":"NIH","award":["P50DK096418"],"award-info":[{"award-number":["P50DK096418"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2019,6,1]]},"abstract":"<jats:p>Fibrosis is a common feature of chronic kidney disease; however, no clinical therapies effectively target the progression of fibrosis. Inhibition of fibronectin polymerization with the small peptide pUR4 attenuates fibrosis in the liver and heart. Here, we show that pUR4 decreases renal fibrosis and tissue remodeling using a clinically relevant model of kidney injury, unilateral ischemia-reperfusion. This work highlights the benefits of inhibiting matrix polymerization, alone or in conjunction with cell-based therapies, as a novel approach to diminish the maladaptive responses to ischemic kidney injury that lead to chronic renal failure.<\/jats:p>","DOI":"10.1152\/ajprenal.00117.2019","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T11:53:10Z","timestamp":1556106790000},"page":"F1293-F1298","source":"Crossref","is-referenced-by-count":31,"title":["Inhibition of fibronectin polymerization alleviates kidney injury due to ischemia-reperfusion"],"prefix":"10.1152","volume":"316","author":[{"given":"Stephanie L. K.","family":"Bowers","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"},{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Davis-Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"},{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"},{"name":"Division of Nephrology and Hypertension, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary M.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"},{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Rudomanova","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"},{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Clark","family":"Bacon","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"},{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Beiersdorfer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"},{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"},{"name":"Division of Nephrology and Hypertension, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasad","family":"Devarajan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"},{"name":"Division of Nephrology and Hypertension, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burns C.","family":"Blaxall","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio"},{"name":"The Heart Institute, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.06.010"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.181081"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M105417200"},{"key":"B4","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1242\/dev.119.4.1079","volume":"119","author":"George EL","year":"1993","journal-title":"Development"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.06.030"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.14.10673"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.09.023"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-3264-3"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2818.2000.00738.x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152153"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070057"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.07.005"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.7255.1"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e02-01-0048"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M103467200"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205360"},{"key":"B17","volume-title":"2013 USRDS Annual Report: Atlas of CKD and ESRD","author":"United States Renal Data System System","year":"2013"},{"key":"B18","volume-title":"2018 USRDS Annual Report: Epidemiology of Kidney Disease in the United States","author":"United States Renal Data System System","year":"2018"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.034609"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206286200"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00431.2011"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00117.2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T19:30:37Z","timestamp":1663356637000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00117.2019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,1]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6,1]]}},"alternative-id":["10.1152\/ajprenal.00117.2019"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00117.2019","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,1]]}}}