{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:52:50Z","timestamp":1792659170523,"version":"4.5.0"},"reference-count":135,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>Vitamin D has proven to be much more than a simple \u201ccalcium hormone.\u201d The fact that the vitamin D receptor has been found in cells not related to mineral metabolism supports that statement. The interest of nephrologists in vitamin D and its effects beyond mineral metabolism has increased over the last few years, evidencing the importance of this so-called \u201csunshine hormone.\u201d In the present review, we highlight the most recent developments in the traditional use of vitamin D in chronic kidney disease (CKD) patients, namely, the control of secondary hyperparathyroidism (sHPT). Furthermore, we also explore the data available regarding the new possible therapeutic uses of vitamin D for the treatment of other complications present in CKD patients, such as vascular calcification, left ventricular hypertrophy, or proteinuria. Finally, some still scarce but very promising data regarding a possible role of vitamin D in kidney transplant patients also are reviewed. The available data point to a potential beneficial effect of vitamin D in CKD patients beyond the control of mineral metabolism.<\/jats:p>","DOI":"10.1152\/ajprenal.00130.2009","type":"journal-article","created":{"date-parts":[[2009,7,23]],"date-time":"2009-07-23T00:55:20Z","timestamp":1248310520000},"page":"F1502-F1509","source":"Crossref","is-referenced-by-count":28,"title":["A new role for vitamin D receptor activation in chronic kidney disease"],"prefix":"10.1152","volume":"297","author":[{"given":"Jos\u00e9 M.","family":"Valdivielso","sequence":"first","affiliation":[{"name":"Laboratorio de Nefrolog\u00eda Experimental, Hospital Universitario Arnau de Vilanova, IRBLLEIDA, Red de Investigati\u00f3n Renal del Instituto de Salud Carlos III (REDinREN ISCIII), Lleida; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Cannata-And\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de Metabolismo \u00d3seo y Mineral, Hospital Universitario Central de Asturias, Instituto Reina Sof\u00eda de Investigaci\u00f3n, REDinREN ISCIII, Universidad de Oviedo, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blai","family":"Coll","sequence":"additional","affiliation":[{"name":"Laboratorio de Nefrolog\u00eda Experimental, Hospital Universitario Arnau de Vilanova, IRBLLEIDA, Red de Investigati\u00f3n Renal del Instituto de Salud Carlos III (REDinREN ISCIII), Lleida; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Laboratorio de Nefrolog\u00eda Experimental, Hospital Universitario Arnau de Vilanova, IRBLLEIDA, Red de Investigati\u00f3n Renal del Instituto de Salud Carlos III (REDinREN ISCIII), Lleida; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00755.x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404865200"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110714"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000164619.49828.7A"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007040406"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2001.6221"},{"key":"B7","first-page":"112","volume":"1","author":"Ayus JC","year":"1981","journal-title":"Semin Nephrol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005040392"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.9.3682-3691.2004"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v31.pm9531176"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000133041.27682.A2"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70064-3"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1993.tb08210.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5728(95)00076-E"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1067\/mlc.2002.122819"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201804200"},{"key":"B17","first-page":"117","volume":"23","author":"Cardus A","year":"2003","journal-title":"Nefrologia"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.08.020"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070305"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000304"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn338"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199805150-00014"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00042.x"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.1.472-487.2005"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.12.1340"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2004.03.061"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.059003855.x"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02961.x"},{"key":"B29","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1681\/ASN.V105980","volume":"10","author":"Finch JL","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"B30","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1681\/ASN.V5122024","volume":"5","author":"Foley RN","year":"1995","journal-title":"J Am Soc Nephrol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.194"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.087288"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1159\/000104875"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116720"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1995.268.4.F746"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000043140.23422.4F"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.11.1174"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.1945"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.121172198"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.2490"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2006.09.028"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2002.01825.x"},{"key":"B43","first-page":"147","volume":"32","author":"Hattori M","year":"1990","journal-title":"Nippon Jinzo Gakkai Shi"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2004.10.001"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602825"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.12.2132"},{"key":"B47","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4757-2861-3","volume-title":"Vitamin D. Physiology, Molecular Biology, and Clinical Applications","author":"Holick MF","year":"1999"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.01.003"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199810150-00002"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2005.00187.x"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.5.879"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2007.00302.x"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.1.136"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001514"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050605"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2001.280.2.F291"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1159\/000088295"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1159\/000233815"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.490"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.5.1289"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00316.2003"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199210000-00046"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1159\/000013384"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215219"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/0895-7061(95)00154-H"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006060573"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25901"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64129-6"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3181761906"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.28582"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2006.01.004"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/11.supp3.22"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.11.1159"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1159\/000183125"},{"key":"B75","first-page":"579","volume":"18","author":"McGonigle RJ","year":"1981","journal-title":"Proc Eur Dial Transplant Assoc"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001542"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002406"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006091028"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2005.07.007"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.343"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.272.4.H1751"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1210\/endo.136.2.7835280"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1159\/000065289"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M310271200"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00775.x"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.189001"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(99)70260-X"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1994.138"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118061"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052939.59093.45"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0401656101"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2006.12.081"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199704150-00005"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00101.x"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.28705"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002458"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00262.2006"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M408903200"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.09.007"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00355.x"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00951.x"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2007.01.017"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.202471299"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.02.015"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg513"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007090993"},{"key":"B107","first-page":"99","volume":"1","author":"Shvil Y","year":"1990","journal-title":"J Am Soc Nephrol"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1021\/jm9802618"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.192"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.4270"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118701"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/0272-6386(95)90455-7"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9808142"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070202"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00878.x"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1989.89"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.2.1049"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006050520"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022536"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004070573"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001868"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/95.12.787"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0805"},{"key":"B124","volume-title":"USRDS 2003 Annual Data Report: Atlas of End-Stage Renal Disease in the United States","author":"US Renal Data System","year":"2003"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2006.02.016"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200005150-00032"},{"key":"B127","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1016\/S0021-9258(18)61537-6","volume":"262","author":"Walters MR","year":"1987","journal-title":"J Biol Chem"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.706127"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002451"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118582"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00224.2004"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705495200"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002572"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803751105"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2006.02.001"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00130.2009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T03:16:37Z","timestamp":1685070997000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00130.2009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":135,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["10.1152\/ajprenal.00130.2009"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00130.2009","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}