{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:06:37Z","timestamp":1791417997979,"version":"4.3.3"},"reference-count":44,"publisher":"American Physiological Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2014,4,15]]},"abstract":"<jats:p>\n                    The proximal renal epithelia express three different Na-dependent inorganic phosphate (P\n                    <jats:sub>i<\/jats:sub>\n                    ) cotransporters: NaPi-IIa\/SLC34A1, NaPi-IIc\/SLC34A3, and PiT2\/SLC20A2. Constitutive mouse knockout models of NaPi-IIa and NaPi-IIc suggested that NaPi-IIa mediates the bulk of renal reabsorption of P\n                    <jats:sub>i<\/jats:sub>\n                    whereas the contribution of NaPi-IIc to this process is minor and probably restricted to young mice. However, many reports indicate that mutations of NaPi-IIc in humans lead to hereditary hypophosphatemic rickets with hypercalciuria (HHRH). Here, we report the generation of a kidney-specific and inducible NaPi-IIc-deficient mouse model based on the loxP-Cre system. We found that the specific removal of the cotransporter from the kidneys of young mice does not impair the capacity of the renal epithelia to transport P\n                    <jats:sub>i<\/jats:sub>\n                    . Moreover, the levels of P\n                    <jats:sub>i<\/jats:sub>\n                    in plasma and urine as well as the circulating levels of parathyroid hormone, FGF-23, and vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    remained unchanged. These findings are in agreement with the data obtained with the constitutive knockout model and suggest that, under steady-state conditions of normal dietary P\n                    <jats:sub>i<\/jats:sub>\n                    , NaPi-IIc is not an essential Na-P\n                    <jats:sub>i<\/jats:sub>\n                    cotransporter in murine kidneys. However, and unlike the constitutive mutants, the kidney-specific depletion of NaPi-IIc does not result in alteration of the homeostasis of calcium. This suggests that the calcium-related phenotype observed in constitutive knockout mice may not be related to inactivation of the cotransporter in kidney.\n                  <\/jats:p>","DOI":"10.1152\/ajprenal.00133.2013","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T01:29:47Z","timestamp":1392859787000},"page":"F833-F843","source":"Crossref","is-referenced-by-count":60,"title":["Renal-specific and inducible depletion of NaPi-IIc\/Slc34a3, the cotransporter mutated in HHRH, does not affect phosphate or calcium homeostasis in mice"],"prefix":"10.1152","volume":"306","author":[{"given":"Komuraiah","family":"Myakala","sequence":"first","affiliation":[{"name":"Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP). University of Zurich, Zurich, Switzerland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Motta","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP). University of Zurich, Zurich, Switzerland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heini","family":"Murer","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP). University of Zurich, Zurich, Switzerland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten A.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP). University of Zurich, Zurich, Switzerland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Koesters","sequence":"additional","affiliation":[{"name":"INSERM UMRS 702, UPMC, Tenon Hospital, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrg","family":"Biber","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP). University of Zurich, Zurich, Switzerland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nati","family":"Hernando","sequence":"additional","affiliation":[{"name":"Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP). 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