{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:29:03Z","timestamp":1778275743569,"version":"3.51.4"},"reference-count":22,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:p>Upregulation of the inducible cyclooxygenase (COX-2) in the macula densa accompanies the activation of the juxtaglomerular apparatus in many high-renin conditions. The functional role of COX-2 in these disease states is poorly understood. We tested whether COX-2 is required to increase renin in renovascular hypertension. Rats with established two-kidney, one-clip (2K1C) hypertension were treated for 2 wk with two different inhibitors of COX-2, NS-398 and rofecoxib, respectively. Hypertension in 2K1C rats was not affected or slightly enhanced by COX-2 inhibition, as measured intra-arterially in conscious animals. The increase in plasma renin activity was also unchanged by both rofecoxib and NS-398. The number of glomeruli with a renin-positive juxtaglomerular apparatus was elevated in clipped kidneys and decreased in contralateral kidneys of 2K1C rats. This pattern was unaltered by COX-2 inhibition. To test the effects of COX-2 blockade on a primarily macula densa-mediated stimulus, we studied salt depletion for comparison. A low-salt diet induced a significant increase in plasma renin activity, which was partially inhibited by treatment with NS-398. We conclude that inhibition of COX-2 in established renovascular hypertension does not affect renin synthesis or release. Thus either COX-2 is not necessary for the macula densa mechanism or the macula densa is not important for maintaining high renin in renovascular hypertension.<\/jats:p>","DOI":"10.1152\/ajprenal.00136.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:37:13Z","timestamp":1425415033000},"page":"F498-F502","source":"Crossref","is-referenced-by-count":26,"title":["Role of macula densa cyclooxygenase-2 in renovascular hypertension"],"prefix":"10.1152","volume":"284","author":[{"given":"Andrea","family":"Hartner","sequence":"first","affiliation":[{"name":"Department of Medicine IV, University of Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Cordasic","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, University of Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarete","family":"Goppelt-Struebe","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, University of Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Veelken","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, University of Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl F.","family":"Hilgers","sequence":"additional","affiliation":[{"name":"Department of Medicine IV, University of Erlangen-N\u00fcrnberg, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1995.269.6.F793"},{"key":"B2","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1681\/ASN.V125867","volume":"12","author":"Castrop H","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5505"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.29.1.297"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117620"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.1.201"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000215"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00209.2001"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s004240100615"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1996.271.3.F659"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00988.x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s004240100616"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.22.5.754"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2001.280.1.F119"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1021\/jm960803q"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/BF00374649"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.24.2.157"},{"key":"B18","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/S0022-3565(24)35402-3","volume":"292","author":"Tegeder I","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1999.277.5.F706"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.34.1.96"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.34.3.503"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.5.F819"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00136.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T17:51:36Z","timestamp":1747763496000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00136.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3,1]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3,1]]}},"alternative-id":["10.1152\/ajprenal.00136.2002"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00136.2002","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3,1]]}}}