{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:01:25Z","timestamp":1778277685932,"version":"3.51.4"},"reference-count":34,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100008732","name":"The Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17POST33670206"],"award-info":[{"award-number":["17POST33670206"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK120790"],"award-info":[{"award-number":["DK120790"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK098141"],"award-info":[{"award-number":["DK098141"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:p> CUL3 mutation (CUL3-\u03949) causes familial hyperkalemic hypertension (FHHt) by reducing adaptor KLHL3, impairing substrate WNK4 degradation. Whether CUL3-\u03949 affects other targets in kidneys remains unclear. We found that CUL3-\u03949 cannot degrade two CUL3 targets, cyclin E and nuclear factor erythroid-2-related factor 2 (NRF2; using a surrogate marker NQO1), or rescue injury or polyuria caused by Cul3 disruption. In an FHHt model, CUL3-\u03949 impaired NRF2 degradation without reduction of its adaptor KEAP1. Our data provide additional insights into CUL3-\u03949 function in the kidney. <\/jats:p>","DOI":"10.1152\/ajprenal.00153.2022","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:20:20Z","timestamp":1661473220000},"page":"F564-F576","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Cullin 3 mutant causing familial hyperkalemic hypertension lacks normal activity in the kidney"],"prefix":"10.1152","volume":"323","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1808-2772","authenticated-orcid":false,"given":"Yujiro","family":"Maeoka","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1389-1493","authenticated-orcid":false,"given":"Ryan J.","family":"Cornelius","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4860-5506","authenticated-orcid":false,"given":"Mohammed Zubaerul","family":"Ferdaus","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7979-0820","authenticated-orcid":false,"given":"Avika","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luan T.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4000-6653","authenticated-orcid":false,"given":"James A.","family":"McCormick","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.01.004"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.18.2375"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17624"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.96700"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021081099"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505444"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-018-1593-z"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017121307"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.91015"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI76126"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40795-0"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.645358"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1865"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00216.2019"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00400.2014"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23056"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2290"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601119200"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.233049"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23095151"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00602.2017"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.08.023"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.07.036"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/srep36185"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-016-0310-y"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14577"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.128578"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.03.023"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nature10814"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2021.07.025"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/13886"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/35095076"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(03)00287-9"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2020101406"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00153.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T17:47:48Z","timestamp":1666201668000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajprenal.00153.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,1]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,11,1]]}},"alternative-id":["10.1152\/ajprenal.00153.2022"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00153.2022","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,1]]},"assertion":[{"value":"2022-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}