{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T09:15:00Z","timestamp":1725527700936},"reference-count":44,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2003,11]]},"abstract":"<jats:p>Cyclooxygenase-2 (COX-2) is involved in kidney morphogenesis and is transiently elevated in the immature kidney. In adult rats, renal cortical COX-2 expression is tonically suppressed by mineralocorticoids (MC) and glucocorticoids (GC) and induced by chronic salt restriction. Young rats have low levels of GC and are in a state of relative volume depletion. The present study was designed to investigate the mechanisms underlying elevated cortical COX-2 expression in the immature kidney. Supplementation of GC or MC suppressed cortical COX-2 expression in suckling rats. GC suppression was significantly, but not completely, prevented by either an MC receptor antagonist or a GC receptor antagonist. MC suppression was completely prevented by a mineralocorticoid receptor antagonist. Salt supplementation suppressed cortical COX-2 expression in a dose- and time-dependent pattern in the suckling rats. Cortical COX-2 expression in the weanling rats was upregulated by a low-salt diet and downregulated by a high-salt diet. These results suggest that relative volume depletion and reduced GC levels are involved in elevated cortical COX-2 expression in the immature rodent kidney.<\/jats:p>","DOI":"10.1152\/ajprenal.00154.2003","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:39:33Z","timestamp":1425415173000},"page":"F881-F888","source":"Crossref","is-referenced-by-count":6,"title":["Regulation of renal cortical cyclooxygenase-2 in young rats"],"prefix":"10.1152","volume":"285","author":[{"given":"Ming-Zhi","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-wan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huifang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"McKanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond C.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3037703"},{"key":"REF2","doi-asserted-by":"crossref","unstructured":"Bostanjoglo M, Reeves WB, Reilly RF, Velazquez H, Robertson N, Litwack G, Morsing P, Dorup J, Bachmann S, and Ellison DH.11\u03b2-Hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules.J Am Soc Nephrol9: 1347-1358, 1998.","DOI":"10.1681\/ASN.V981347"},{"key":"REF3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10318"},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5505"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1485"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.1038\/378406a0"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1159\/000240538"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1097\/00041552-199611000-00001"},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1990.314"},{"key":"REF10","doi-asserted-by":"publisher","DOI":"10.1126\/science.2845584"},{"key":"REF11","doi-asserted-by":"crossref","unstructured":"Harris RC.Cyclooxygenase-2 in the kidney.J Am Soc Nephrol11: 2387-2394, 2000.","DOI":"10.1681\/ASN.V11122387"},{"key":"REF12","doi-asserted-by":"crossref","unstructured":"Harris RCand Breyer MD.Physiological regulation of cyclooxygenase-2 in the kidney.Am J Physiol Renal Physiol281: F1-F11, 2001.","DOI":"10.1152\/ajprenal.2001.281.1.F1"},{"key":"REF13","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117620"},{"key":"REF14","doi-asserted-by":"crossref","unstructured":"Henning SJ.Plasma concentrations of total and free corticosterone during development in the rat.Am J Physiol Endocrinol Metab Gastrointest Physiol235: E451-E456, 1978.","DOI":"10.1152\/ajpendo.1978.235.5.E451"},{"key":"REF15","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.449"},{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00564.x"},{"key":"REF17","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2001.280.6.F1001"},{"key":"REF18","doi-asserted-by":"publisher","DOI":"10.1016\/S0085-2538(15)46757-2"},{"key":"REF19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4445"},{"key":"REF20","doi-asserted-by":"crossref","unstructured":"Kujubu DA, Fletcher BS, Varnum BC, Lim RW, and Herschman HR.TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase\/cyclooxygenase homologue.J Biol Chem266: 12866-12872, 1991.","DOI":"10.1016\/S0021-9258(18)98774-0"},{"key":"REF21","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.39"},{"key":"REF22","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90126-4"},{"key":"REF23","unstructured":"Larsson LI.Immunocytochemistry: Theory and Practice. 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