{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:24:24Z","timestamp":1792599864250,"version":"4.5.0"},"reference-count":31,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p>\n                    Lower urinary tract function is regulated by spinal and supraspinal reflexes that coordinate the activity of the urinary bladder and external urethral sphincter (EUS). Two types of EUS activity (tonic and bursting) have been identified in rats. This study in urethane-anesthetized female rats used cystometry, EUS electromyography, spinal cord transection (SCT) at different segmental levels, and analysis of the effects of 5-HT\n                    <jats:sub>1A<\/jats:sub>\n                    receptor agonist (8-OH-DPAT) and antagonist (WAY100635) drugs to examine the origin of tonic and bursting EUS activity. EUS activity was elicited by bladder distension or electrical stimulation of afferent axons in the pelvic nerve (pelvic-EUS reflex). Tonic activity evoked by bladder distension was detected in spinal cord-intact rats and after acute and chronic T8\u20139 or L3\u20134 SCT but was abolished after L6\u2013S1 SCT. Bursting activity was abolished by all types of SCT except chronic T8\u20139 transection. 8-OH-DPAT enhanced tonic activity, and WAY100635 reversed the effect of 8-OH-DPAT. The pelvic-EUS reflex consisted of an early response (ER) and late response (LR) when the bladder was distended in spinal cord-intact rats. ER remained after acute or chronic T8\u20139 and L3\u20134 SCT, but was absent after L6\u2013S1 SCT. LR occurred only in chronic T8\u20139 SCT rats where it was enhanced or unmasked by 8-OH-DPAT. The results indicate that spinal serotonergic mechanisms facilitate tonic and bursting EUS activity. The circuitry for generating different patterns of EUS activity appears to be located in different segments of the spinal cord: tonic activity at L6\u2013S1 and bursting activity between T8\u20139 and L3\u20134.\n                  <\/jats:p>","DOI":"10.1152\/ajprenal.00175.2006","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T23:37:01Z","timestamp":1161128221000},"page":"F1044-F1053","source":"Crossref","is-referenced-by-count":103,"title":["Serotonergic drugs and spinal cord transections indicate that different spinal circuits are involved in external urethral sphincter activity in rats"],"prefix":"10.1152","volume":"292","author":[{"given":"Hui-Yi","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Li","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Jin J.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"de Groat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","unstructured":"Chang HY\n                      , Cheng CL, Chen JJ, de Groat WC.\n                      Role of glutamatergic and serotonergic mechanisms in urethral sphincter reflexes in urethane-anesthetized rats.\n                      2004 Abstract Viewer\n                      (Online). Program No. 541.13. Society for Neuroscience. http:\/\/www.sfn.org."},{"key":"R2","unstructured":"Chang HY\n                      , Cheng CL, Chen JJ, Negoita FA, de Groat WC.\n                      Influence of serotonergic mechanisms in the spinal cord on external urethral sphincter function during voiding.\n                      2005 Abstract Viewer\n                      (Online). Program No. 48.17. Society for Neuroscience. http:\/\/www.sfn.org."},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.06.002"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2004.02.014"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00212-9"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2004.08.023"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(01)01636-3"},{"key":"R8","unstructured":"de Groat WC\n                      , Booth AM, Yoshimura N.\n                      Neurophysiology of micturition and its modification in animal models of human disease. In:\n                      The Autonomic Nervous System: Nervous Control of the Urogenital System,\n                      edited by Maggi CA. London, UK: Harwood, 1993, p. 247\u2013289."},{"key":"R9","doi-asserted-by":"crossref","unstructured":"de Groat WC\n                      , Yoshimura N.\n                      Mechanisms underlying the recovery of lower urinary tract function following spinal cord injury.\n                      Progr Brain Res\n                      152\n                      : 59\u201384, 2005.","DOI":"10.1016\/S0079-6123(05)52005-3"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000080708.87092.cc"},{"key":"R11","unstructured":"Dolber PC\n                      , Gu C, Fraser MO, Thor KB.\n                      Relief of bladder-sphincter dyssynergia by a 5HT1A serotonin receptor agonist in rats with chronic spinal cord injury.\n                      2003 Abstract Viewer\n                      . Program No. 608.16. Society for Neuroscience. http:\/\/www.sfn.org."},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1998.15.451"},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Ishiura Y\n                      , Yoshiyama M, Yokoyama O, Namiki M, de Groat WC.\n                      Central muscarinic mechanisms regulating voiding in rats.\n                      J Pharmacol Exp Ther\n                      297\n                      : 933\u2013939, 2001.","DOI":"10.1016\/S0022-3565(24)29617-8"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.280.5.R1407"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1993.264.6.R1157"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90503-D"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91758-9"},{"key":"R18","unstructured":"Lecci A\n                      , Giuliani S, Santicioli P, Maggi CA.\n                      Involvement of 5-hydroxytryptamine 1A receptors in the modulation of micturition reflexes in the anesthetized rat.\n                      J Pharmacol Exp Ther\n                      262\n                      : 181\u2013189, 1992."},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1989.257.2.R410"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1986.251.2.R250"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19971229)389:4<584::AID-CNE4>3.0.CO;2-X"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1991.261.5.R1276"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(89)90130-6"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-198610000-00003"},{"key":"R25","unstructured":"Testa R\n                      , Guarneri L, Poggesi E, Angelico P, Velasco C, Ibba M, Cilia A, Motta G, Riva C, Leonardi A.\n                      Effect of several 5-hydroxytryptamine\n                      1A\n                      receptor ligands on the micturition reflex in rats: comparison with WAY100635.\n                      J Pharmacol Exp Ther\n                      290\n                      : 1258\u20131269, 1999."},{"key":"R26","unstructured":"Thor KB\n                      , Katofiasc MA.\n                      Effects of duloxetine, a combined serotonin and norepinephrine reuptake inhibitor, on central neural control of lower urinary tract function in the chloralose-anesthetized female cat.\n                      J Pharmacol Exp Ther\n                      274\n                      : 1014\u20131024, 1995."},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02897-4"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(93)90469-V"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1126\/science.1073885"},{"key":"R30","doi-asserted-by":"crossref","unstructured":"Yoshiyama M\n                      , Yamamoto T, de Groat WC.\n                      Role of spinal alpha(1)-adrenergic mechanisms in the control of lower urinary tract in the rat.\n                      Brain Res\n                      882\n                      : 36\u201344, 2002.","DOI":"10.1016\/S0006-8993(00)02688-3"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(00)00474-X"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00175.2006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T10:54:17Z","timestamp":1736592857000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00175.2006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["10.1152\/ajprenal.00175.2006"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00175.2006","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}