{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:34:51Z","timestamp":1791513291927,"version":"4.3.4"},"reference-count":176,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>\n                    The discovery of the renal outer medullary K\n                    <jats:sup>+<\/jats:sup>\n                    channel (ROMK, K\n                    <jats:sub>ir<\/jats:sub>\n                    1.1), the founding member of the inward-rectifying K\n                    <jats:sup>+<\/jats:sup>\n                    channel (K\n                    <jats:sub>ir<\/jats:sub>\n                    ) family, by Ho and Hebert in 1993 revolutionized our understanding of potassium channel biology and renal potassium handling. Because of the central role that ROMK plays in the regulation of salt and potassium homeostasis, considerable efforts have been invested in understanding the underlying molecular mechanisms. 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