{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:11:10Z","timestamp":1791411070532,"version":"4.3.3"},"reference-count":23,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p> Patients with renal insufficiency develop secondary hyperparathyroidism. Monotherapy with active vitamin D or calcimimetics ameliorates secondary hyperparathyroidism. We compared kidney damage in subtotally nephrectomized (SNX) rats treated with active vitamin D (calcitriol) or the calcimimetic R-568. Male Sprague-Dawley SNX and sham-operated (sham-op) rats were randomized into the following treatment groups: SNX + R-568, SNX + calcitriol, SNX + vehicle, sham-op + R-568, sham-op + calcitriol, and sham-op + vehicle. Albuminuria and blood pressure were monitored and kidneys were examined using morphometry, immunohistochemistry, quantitative RT-PCR, and in situ hybridization. Parathyroid hormone concentrations were lowered to the same extent by the two interventions, although phosphorus and the calcium-phosphorus product were reduced only by R-568 treatment. SNX rats developed marked albuminuria, which was significantly reduced in ad libitum- and pair-fed animals treated with R-568 and animals treated with calcitriol. Mean glomerular volume (6.05 \u00b1 1.46 vs. 2.70 \u00b1 0.91 mm<jats:sup>3<\/jats:sup>), podocyte volume (831 \u00b1 127 vs. 397 \u00b1 67 \u03bcm<jats:sup>3<\/jats:sup>), the degree of foot process fusion (mean width of foot processes = 958 \u00b1 364 vs. 272 \u00b1 35 nm), and glomerular basement membrane thickness (244 \u00b1 6 vs. 267 \u00b1 23 nm), as well as desmin staining, were significantly higher in vehicle-treated SNX than sham-operated animals. These changes were ameliorated with R-568 and calcitriol. In SNX, as well as sham-operated, animals, expression of the calcium-sensing receptor (protein and mRNA) was upregulated by treatment with the calcimimetic, but not calcitriol. Calcitriol and R-568 were similarly effective in ameliorating kidney damage. <\/jats:p>","DOI":"10.1152\/ajprenal.00220.2007","type":"journal-article","created":{"date-parts":[[2008,1,17]],"date-time":"2008-01-17T01:25:58Z","timestamp":1200533158000},"page":"F748-F757","source":"Crossref","is-referenced-by-count":47,"title":["Calcimimetic R-568 or calcitriol: equally beneficial on progression of renal damage in subtotally nephrectomized rats"],"prefix":"10.1152","volume":"294","author":[{"given":"Grzegorz","family":"Piecha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor","family":"Kokeny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadezda","family":"Koleganova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman","family":"Geldyyev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard","family":"Ritz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus Peter","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Luise","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000095248.91994.D3"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00755.x"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/11.6.1003"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031633"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.11.2939"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1987.189"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.28"},{"key":"R8","unstructured":"Fox J, Lowe SH, Petty BA, Nemeth EF. 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