{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:27:38Z","timestamp":1773300458412,"version":"3.50.1"},"reference-count":37,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p>Transient administration of ANG II causes persistent salt-sensitive hypertension associated with arteriolopathy, interstitial inflammation, and cortical vasoconstriction; blocking the vascular and inflammatory changes with mycophenolate mofetil (MMF) prevents vasoconstriction. While infiltrating leukocytes during the salt-sensitive hypertension phase express ANG II, the functional role of ANG II during this phase is not known. We examined the acute effect of candesartan on renal hemodynamics during the established salt-sensitive hypertensive phase and related these findings to direct measurement of intrarenal ANG II and inflammatory cells in rats previously exposed to ANG II with or without MMF treatment. Sham controls were also examined. The administration of ANG II, followed by exposure to high-salt diet, resulted in hypertension, cortical vasoconstriction, an increase in interstitial inflammatory cells (44.8 \u00b1 1.3 lymphocytes\/mm<jats:sup>2<\/jats:sup>, and 30.8 \u00b1 1.2 macrophages\/mm<jats:sup>2<\/jats:sup>ANG II vs. 19.6 \u00b1 2 lymphocytes\/mm<jats:sup>2<\/jats:sup>, and 22 \u00b1 0.7 macrophages\/mm<jats:sup>2<\/jats:sup>Sham), and increase in renal ANG II levels (1,358 \u00b1 74.6 pg\/ml ANG II vs. 194 \u00b1 9.28 pg\/ml Sham). Treatment with MMF during the administration of exogenous ANG II resulted in reduction in renal interstitial inflammation (19.7 \u00b1 0.9 lymphocytes\/mm<jats:sup>2<\/jats:sup>and 15.9 \u00b1 0.8 machophages\/mm<jats:sup>2<\/jats:sup>), ANG II levels (436.9 \u00b1 52.29 pg\/ml), cortical vasoconstriction, and stable blood pressure levels during the subsequent challenge with a high-salt diet. Acute administration of candesartan similarly reduced renal vasoconstriction and blood pressure. We conclude that the cortical vasoconstriction occurring with salt-sensitive hypertension following exposure to ANG II is mediated by intrarenal ANG II, related, at least in part, to the interstitial inflammation.<\/jats:p>","DOI":"10.1152\/ajprenal.00221.2006","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T02:28:45Z","timestamp":1153880925000},"page":"F1281-F1287","source":"Crossref","is-referenced-by-count":38,"title":["Angiotensin II, interstitial inflammation, and the pathogenesis of salt-sensitive hypertension"],"prefix":"10.1152","volume":"291","author":[{"given":"Martha","family":"Franco","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"Rodr\u00edguez-Iturbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard J.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Santamar\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e9lica","family":"Montoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas","family":"Nepomuceno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Bautista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edilia","family":"Tapia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Herrera-Acosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00192.2002"},{"key":"R2","doi-asserted-by":"crossref","unstructured":"Azar S, Tobian L, and Johnson MA.Glomerular, efferent arteriolar, peritubular capillary, and tubular pressures in hypertension.Am J Physiol227: 1045\u20131050, 1974.","DOI":"10.1152\/ajplegacy.1974.227.5.1045"},{"key":"R3","unstructured":"Blantz RCand Tucker BJ.Measurements of glomerular dynamics. 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