{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:36:29Z","timestamp":1785418589546,"version":"3.56.0"},"reference-count":38,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["31003A-182478\/1"],"award-info":[{"award-number":["31003A-182478\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p>\n                    We explore the role of the serine protease CAP1\/Prss8 in aldosterone synthesis. Described previously as a candidate gene for hypertension, the mechanism by which renal serine protease deficiency is implicated in aldosterone production is still largely unknown. Our findings underscore a role of prostasin in the regulation of aldosterone synthesis. In kidney-specific CAP1\/Prss8 knockout mice, K\n                    <jats:sup>+<\/jats:sup>\n                    supplementation is predominant over Na\n                    <jats:sup>+<\/jats:sup>\n                    and restores normal aldosterone production proposing new pathways to treat hypo- or hypertension.\n                  <\/jats:p>","DOI":"10.1152\/ajprenal.00224.2025","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:40:27Z","timestamp":1757698827000},"page":"F573-F580","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary K\n                    <sup>+<\/sup>\n                    supplementation restores normal aldosterone level in Na\n                    <sup>+<\/sup>\n                    -deprived renal tubule-specific CAP1\/Prss8-deficient 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