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Lack of ultrasensitive bioanalytical tools has hindered the discovery of low abundant urinary biomarkers in ADTKD. Here, we developed an ultrasensitive plasmon-enhanced fluorescence-linked immunosorbent assay (p-FLISA). p-FLISA demonstrated that secreted immunoglobulin heavy chain-binding protein is an early urinary endoplasmic reticulum stress biomarker in ADTKD- UMOD, which will be valuable in monitoring disease progression and the treatment response in ADTKD. <\/jats:p>","DOI":"10.1152\/ajprenal.00231.2021","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T13:40:36Z","timestamp":1626097236000},"page":"F236-F244","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Ultrabright plasmonic fluor nanolabel-enabled detection of a urinary ER stress biomarker in autosomal dominant tubulointerstitial kidney disease"],"prefix":"10.1152","volume":"321","author":[{"given":"Yeawon","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, 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