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Proteinuria and serum creatinine and blood urea nitrogen concentrations were measured on days 0, 5, 10, 15, and 30, and systolic blood pressure was recorded on days 0, 15, and 30. The degree of glomerulosclerosis and tubulointerstitial damage, the immunostaining for inducible nitric oxide synthase, 3-nitrotyrosine, poly(ADP-ribose), and the subunits of NADPH oxidase p22<jats:sup>phox<\/jats:sup>and gp91<jats:sup>phox<\/jats:sup>, and the activity of SOD were determined on day 30. SAC and AG reduced hypertension, renal damage, and the abundance of inducible nitric oxide synthase, 3-nitrotyrosine, poly(ADP-ribose), p22<jats:sup>phox<\/jats:sup>, and gp91<jats:sup>phox<\/jats:sup>and increased SOD activity. Our data suggest that the antihypertensive and renoprotective effects of SAC and AG are associated with their antioxidant properties and that they may be used to ameliorate hypertension and delay the progression of renal damage.<\/jats:p>","DOI":"10.1152\/ajprenal.00235.2007","type":"journal-article","created":{"date-parts":[[2007,8,9]],"date-time":"2007-08-09T01:04:03Z","timestamp":1186621443000},"page":"F1691-F1698","source":"Crossref","is-referenced-by-count":61,"title":["Renoprotective and antihypertensive effects of<i>S<\/i>-allylcysteine in 5\/6 nephrectomized rats"],"prefix":"10.1152","volume":"293","author":[{"given":"Cristino","family":"Cruz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Correa-Rotter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores 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