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Acute vasoconstriction of renal arteries by ANG was blunted in Noxa1<jats:sup>\u2212\/\u2212<\/jats:sup> compared with wild-type mice. NOXA1\/NOX1\/O<jats:sub>2<\/jats:sub><jats:sup>\u2022\u2212<\/jats:sup> signaling was also observed in ANG II stimulation of vascular smooth muscle cells and isolated mesenteric resistance arteries, indicating that it contributes to ANG II-induced hypertension. 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