{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:18:07Z","timestamp":1791191887007,"version":"4.1.0"},"reference-count":34,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association (AHA)","doi-asserted-by":"publisher","award":["14SDG18060004"],"award-info":[{"award-number":["14SDG18060004"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003172","name":"National Kidney Foundation of Maryland (NKF-MD)","doi-asserted-by":"publisher","award":["PDA"],"award-info":[{"award-number":["PDA"]}],"id":[{"id":"10.13039\/100003172","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["P30DK090868"],"award-info":[{"award-number":["P30DK090868"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2015,9,15]]},"abstract":"<jats:p>The human propensity for high levels of serum uric acid (SUA) is a trait that has defied explanation. Is it beneficial? Is it pathogenic? Its role in the human diseases like gout and kidney stones was discovered over a century ago [Richette P, Bardin T. Lancet 375: 318\u2013328, 2010; Rivard C, Thomas J, Lanaspa MA, Johnson RJ. Rheumatology (Oxford) 52: 421\u2013426, 2013], but today emerging new genetic and epidemiological techniques have revived an age-old debate over whether high uric acid levels (hyperuricemia) independently increase risk for diseases like hypertension and chronic kidney disease [Feig DI. J Clin Hypertens (Greenwich) 14: 346\u2013352, 2012; Feig DI, Madero M, Jalal DI, Sanchez-Lozada LG, Johnson RJ. J Pediatr 162: 896\u2013902, 2013; Feig DI, Soletsky B, Johnson RJ. JAMA 300: 924\u2013932, 2008; Wang J, Qin T, Chen J, Li Y, Wang L, Huang H, Li J. PLoS One 9: e114259, 2014; Zhu P, Liu Y, Han L, Xu G, Ran JM. PLoS One 9: e100801, 2014]. Part of the mystery of the role uric acid plays in human health stems from our lack of understanding of how humans regulate uric acid homeostasis, an understanding that could shed light on the historic role of uric acid in human adaptation and its present role in human pathogenesis. This review will highlight the recent work to identify the first important human uric acid secretory transporter, ABCG2, and the identification of a common causal ABCG2 variant, Q141K, for hyperuricemia and gout.<\/jats:p>","DOI":"10.1152\/ajprenal.00242.2015","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T02:41:05Z","timestamp":1435804865000},"page":"F485-F488","source":"Crossref","is-referenced-by-count":51,"title":["ABCG2: the molecular mechanisms of urate secretion and gout"],"prefix":"10.1152","volume":"309","author":[{"given":"Owen M.","family":"Woodward","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1401037111"},{"key":"B2","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/S0022-2275(20)31588-1","volume":"42","author":"Dean M","year":"2001","journal-title":"J Lipid Res"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61343-4"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1126\/science.1722350"},{"key":"B5","first-page":"44","volume":"31","author":"Esparza Martin N","year":"2011","journal-title":"Nefrologia"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7176.2012.00662.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.12.078"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.300.8.924"},{"key":"B9","first-page":"287","volume":"34","author":"Gutman AB","year":"1958","journal-title":"Bull NY Acad Med"},{"key":"B10","first-page":"353","volume":"74","author":"Gutman AB","year":"1961","journal-title":"Trans Assoc Am Physicians"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1124\/mol.110.065862"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2500"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021113-170343"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/srep02014"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000237"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.11.023"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11669"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-004-0931-x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32835ddad2"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/srep05227"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.11.024"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60883-7"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes297"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1994.266.5.F797"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608312103"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.06.054"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.112.196980"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddr307"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114259"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0901249106"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2011.08171.x"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214530110"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15059149"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100801"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00242.2015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T17:00:55Z","timestamp":1652720455000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00242.2015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,15]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,9,15]]}},"alternative-id":["10.1152\/ajprenal.00242.2015"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00242.2015","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,15]]}}}