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RPTC PP2A B55\u03b1 is thus a key AT\n                    <jats:sub>2<\/jats:sub>\n                    R signaling intermediate and potential therapeutic target to promote sodium excretion in hypertensive individuals. This study introduces knocking down B55\u03b1 in vivo specifically in RPTCs using renal interstitial infusion of siRNA as a novel and unique approach to investigate physiological protein function in the kidney.\n                  <\/jats:p>","DOI":"10.1152\/ajprenal.00256.2025","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:10:07Z","timestamp":1766020207000},"page":"F102-F117","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Protein phosphatase 2A subunit B55 alpha is required for angiotensin type 2 receptor elicited natriuresis"],"prefix":"10.1152","volume":"330","author":[{"given":"John J.","family":"Gildea","sequence":"first","affiliation":[{"name":"University of Virginia School of Medicine","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"University of 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