{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:51:00Z","timestamp":1793321460899,"version":"4.5.0"},"reference-count":28,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2003,2,1]]},"abstract":"<jats:p>A<jats:sub>3<\/jats:sub>adenosine receptor (AR) activation and inhibition worsen and improve, respectively, renal function after ischemia-reperfusion (I\/R) injury in rats. We sought to further characterize the role of A<jats:sub>3<\/jats:sub>ARs in modulating renal function after either I\/R or myoglobinuric renal injury. A<jats:sub>3<\/jats:sub>knockout mice had significantly lower plasma creatinines compared with C57 controls 24 h after I\/R or myoglobinuric renal injury. C57 control mice pretreated with the A<jats:sub>3<\/jats:sub>AR antagonist [3-ethyl-5-benzyl-2-methyl-4-phenylethynyl-6-phenyl-1,4-(\u00b1)-dihydropyridine-3,5 dicarboxylate] or agonist [0.125 mg\/kg N<jats:sup>6<\/jats:sup>-(3-iodobenzyl)- N-methyl-5\u2032-carbamoyladenosine (IB-MECA)] demonstrated improved or worsened renal function, respectively, after I\/R or myoglobinuric renal injury. Higher doses of IB-MECA were lethal in C57 mice subjected to renal ischemia. H<jats:sub>1<\/jats:sub>but not H<jats:sub>2<\/jats:sub>histamine receptor antagonist prevented death in mice pretreated with IB-MECA before renal ischemia. Improvement in renal function was associated with significantly improved renal histology. In conclusion, preischemic A<jats:sub>3<\/jats:sub>AR activation (0.125 mg\/kg IB-MECA) exacerbated renal I\/R injury in mice. Mice lacking A<jats:sub>3<\/jats:sub>ARs or blocking A<jats:sub>3<\/jats:sub>ARs in wild-type mice resulted in significant renal protection from ischemic or myoglobinuric renal failure.<\/jats:p>","DOI":"10.1152\/ajprenal.00271.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:37:06Z","timestamp":1425415026000},"page":"F267-F273","source":"Crossref","is-referenced-by-count":81,"title":["A<sub>3<\/sub>adenosine receptor knockout mice are protected against ischemia- and myoglobinuria-induced renal failure"],"prefix":"10.1152","volume":"284","author":[{"given":"H. 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