{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:30:58Z","timestamp":1758709858157},"reference-count":46,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2002,1,1]]},"abstract":"<jats:p>The tubular localization of 1,25-dihydroxyvitamin D[1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>]-stimulated calmodulin binding proteins (CaMBP-Ds) in the rat kidney and the specificity of their induction were characterized to better understand renal responses to protracted 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>treatment in vivo. None of the other hormones tested (parathyroid hormone, calcitonin, estradiol-17\u03b2, testosterone, progesterone, hydrocortisone, or dexamethasone) stimulated the CaMBP-Ds, whereas maximal 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>stimulation occurred after a 5- to 7-day treatment with 100 ng\/day 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>. With the exception of the more ubiquitously distributed CaMBP-D150, the CaMBP-Ds were localized in distal, but not proximal, tubule preparations. 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>induction of vitamin D receptors and the CaMBP-Ds was similar with respect to dose-response and time course. Finally, the CaMBP-Ds remained elevated for at least 4 wk after 1,25(OH)<jats:sub>2<\/jats:sub>D<jats:sub>3<\/jats:sub>withdrawal. Because the vitamin D-stimulated renal CaMBP-Ds are principally proteins of the distal tubule, they may be associated with renal regulation of Ca<jats:sup>2+<\/jats:sup>homeostasis. The sustained induction of CaMBP-Ds is important in addressing the question of whether their induction is a function of normal Ca<jats:sup>2+<\/jats:sup>homeostasis or a pathophysiological consequence of hypervitaminosis D and hypercalcemia.<\/jats:p>","DOI":"10.1152\/ajprenal.00286.2000","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:33:25Z","timestamp":1425414805000},"page":"F77-F84","source":"Crossref","is-referenced-by-count":12,"title":["1,25-Dihydroxyvitamin D-stimulated calmodulin binding proteins: a sustained effect on distal tubules"],"prefix":"10.1152","volume":"282","author":[{"given":"Emmanuel K. 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