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Recently, mutations in scaffold protein membrane-associated guanylate kinase inverted 2 (MAGI-2) encoding gene were identified among the etiology of steroid-resistant nephrotic syndrome. MAGI-2 interacts with core proteins of multiple pathways, such as transforming growth factor-\u03b2 signaling, planar cell polarity pathway, and Wnt\/\u03b2-catenin signaling in podocyte and slit diaphragm. Through the interaction with its ligand, MAGI-2 modulates the regulation of apoptosis, cytoskeletal reorganization, and glomerular development. This review aims to summarize recent findings on the role of MAGI-2 and some other scaffold proteins, such as nephrin and synaptopodin, in the underlying mechanisms of glomerulopathy.<\/jats:p>","DOI":"10.1152\/ajprenal.00292.2018","type":"journal-article","created":{"date-parts":[[2018,8,15]],"date-time":"2018-08-15T21:09:48Z","timestamp":1534367388000},"page":"F1336-F1344","source":"Crossref","is-referenced-by-count":12,"title":["MAGI-2 and scaffold proteins in glomerulopathy"],"prefix":"10.1152","volume":"315","author":[{"given":"Maulana A.","family":"Empitu","sequence":"first","affiliation":[{"name":"Department of Nephrology, Graduate School of Medicine, Chiba University, Chiba, Japan"},{"name":"Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ika N.","family":"Kadariswantiningsih","sequence":"additional","affiliation":[{"name":"Department of Nephrology, 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