{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:28:57Z","timestamp":1778275737490,"version":"3.51.4"},"reference-count":24,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p> In the current experiments, we determined the response of plasma renin concentration (PRC) to acute intraperitoneal administration of furosemide (40 mg\/kg), hydralazine (2 mg\/kg), isoproterenol (10 mg\/kg), candesartan (50 \u03bcg), or quinaprilate (50 \u03bcg) in conscious wild-type (WT) and cyclooxygenase (COX)-2\u2212\/\u2212 mice on three different genetic backgrounds (mixed, C57BL\/6, 129J). PRC was measured in plasma obtained by tail vein puncture. Basal PRC was significantly lower in COX-2\u2212\/\u2212 than WT mice independent of genetic background (51, 10, and 17% of WT in mixed, 129J, and C57BL\/6). All five acute interventions caused significant increases of PRC in both COX-2+\/+ and \u2212\/\u2212 mice, but the response was consistently less in COX-2-deficient mice (e.g., \u0394PRC in ng ANG I\u00b7ml<jats:sup>\u22121<\/jats:sup>\u00b7h<jats:sup>\u22121<\/jats:sup> caused by furosemide, isoproterenol, hydralazine, quinaprilate, or candesartan 4,699 \u00b1 544, 3,534 \u00b1 957, 2,522 \u00b1 369, 9,453 \u00b1 1,705, 66,455 \u00b1 21,938 in 129J WT, and 201 \u00b1 78, 869 \u00b1 275, 140 \u00b1 71, 902 \u00b1 304, 2,660 \u00b1 954 in 129J COX-2\u2212\/\u2212). A low-NaCl diet and enalapril for 1 wk caused a 14-fold elevation of PRC in COX-2\u2212\/\u2212 mice and was associated with a greatly increased PRC response to acute furosemide (\u0394PRC 201 \u00b1 78 before and 15,984 \u00b1 2,397 after low Na\/enalapril). As measured by radiotelemetry, blood pressure and heart rate responses to furosemide, hydralazine, isoproterenol, candesartan, or quinaprilate were not different between COX-2 genotypes. In conclusion, chronic absence of COX-2 reduces renin expression, release, and PRC and is associated with a reduced ability to alter PRC during acute stimulation regardless of the nature of the stimulus. COX-2 activity does not appear to be a mandatory and specific requirement for furosemide-stimulated renin secretion. <\/jats:p>","DOI":"10.1152\/ajprenal.00317.2006","type":"journal-article","created":{"date-parts":[[2006,9,6]],"date-time":"2006-09-06T03:45:28Z","timestamp":1157514328000},"page":"F415-F422","source":"Crossref","is-referenced-by-count":45,"title":["Low plasma renin and reduced renin secretory responses to acute stimuli in conscious COX-2-deficient mice"],"prefix":"10.1152","volume":"292","author":[{"given":"Soo Mi","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Limeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Mizel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuning G.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josie P.","family":"Briggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jurgen","family":"Schnermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.2001.5.2.89"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.35.2.e1"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Castrop H, Schweda F, Mizel D, Huang Y, Briggs J, Kurtz A, Schnermann J. 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