{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T10:44:02Z","timestamp":1715597042920},"reference-count":25,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:p> Because across-the-board data indicate that renin and cyclooxygenase-2 (COX-2) expression in the kidney cortex are regulated in parallel and because ANG II can inhibit COX-2 expression, the purpose of our study was to characterize a potential general inhibitory feedback of the renin-angiotensin system on renocortical COX-2 expression in vivo. Rats were fed a high-, normal-, or low-salt diet or were chronically infused with furosemide (60 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup> \u00b7 day<jats:sup>\u22121<\/jats:sup>) or the left renal artery was clipped, and the animals were treated in addition to or without the angiotensin-converting enzyme inhibitor ramipril (10 mg \u00b7 kg<jats:sup>\u22121<\/jats:sup> \u00b7 day<jats:sup>\u22121<\/jats:sup>). A high-salt diet reduced expression of COX-2, whereas a low-salt diet, furosemide infusion, and renal artery stenosis stimulated COX-2 expression. Additional angiotensin-converting enzyme inhibition led to further increases in renocortical COX-2 expression by 62, 136, 300, 50, and 70% for a high-, normal-, and low-salt diet, furosemide infusion, and renal artery stenosis, respectively. Thus our data suggest a general inhibitory effect of the renin-angiotensin system on renocortical COX-2 expression. <\/jats:p>","DOI":"10.1152\/ajprenal.00338.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:37:13Z","timestamp":1425415033000},"page":"F518-F524","source":"Crossref","is-referenced-by-count":11,"title":["General inhibition of renocortical cyclooxygenase-2  expression by the renin-angiotensin system"],"prefix":"10.1152","volume":"284","author":[{"given":"Hayo","family":"Castrop","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Physiologie und"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Klar","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physiologie und"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physiologie und"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"H\u00f6cherl","sequence":"additional","affiliation":[{"name":"Pharmakologie der Universit\u00e4t Regensburg, D-93040 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Kurtz","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physiologie und"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10318"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5505"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2001.280.3.F449"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1601"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1993.265.4.F578"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200018080-00016"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117620"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.1.201"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s004240100615"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00464.2001"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2001.280.1.F119"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00466.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.55.070186.000441"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.11.4888"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.36.2.276"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(99)70056-1"},{"key":"B18","first-page":"290","volume":"46","author":"Stichtenoth DO","year":"1998","journal-title":"J Investig Med"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1999.277.5.F706"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.30.3.687"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.34.1.96"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.34.3.503"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.2000.279.5.F819"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M006218200"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1998.274.3.F481"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00338.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T22:14:45Z","timestamp":1567980885000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00338.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3,1]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3,1]]}},"alternative-id":["10.1152\/ajprenal.00338.2002"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00338.2002","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,3,1]]}}}