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Renal vascular morphology is particularly challenging, since many arterial walls are partially wrapped by the walls of veins. In the absence of a precise characterization of three-dimensional branching vascular geometry, accurate computational modeling of the intrarenal transport of small diffusible molecules is impossible. An enormous manual effort was required to achieve a relatively precise characterization of rat renal vascular geometry, highlighting the need for an automated method for analysis of branched vasculature morphology to allow characterization of the renal vascular geometry of other species, including humans. We present a semisupervised method for three-dimensional morphometric analysis of renal vasculature images generated by computed tomography. We derive quantitative vascular attributes important to mass transport between arteries, veins, and the renal tissue and present methods for their computation for a three-dimensional vascular geometry. To validate the algorithm, we compare automated vascular estimates with subjective manual measurements for a portion of rabbit kidney. Although increased image resolution can improve outcomes, our results demonstrate that the method can quantify the morphological characteristics of artery-vein pairs, comparing favorably with manual measurements. Similar to the rat, we show that rabbit artery-vein pairs become less intimate along the course of the renal vasculature, but the total wrapped mass transfer coefficient increases and then decreases. This new method will facilitate new quantitative physiological models describing the transport of small molecules within the kidney.<\/jats:p>","DOI":"10.1152\/ajprenal.00339.2017","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T00:10:18Z","timestamp":1505952618000},"page":"F715-F725","source":"Crossref","is-referenced-by-count":15,"title":["Three-dimensional morphometric analysis of the renal vasculature"],"prefix":"10.1152","volume":"314","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6294-0688","authenticated-orcid":false,"given":"Zohaib","family":"Khan","sequence":"first","affiliation":[{"name":"School of Information Technology and Mathematical Sciences, University of South Australia, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9980-9640","authenticated-orcid":false,"given":"Jennifer P.","family":"Ngo","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program, Biosciences Discovery Institute and Department of Physiology, Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Le","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program, Biosciences Discovery Institute and Department of Physiology, Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9241-0757","authenticated-orcid":false,"given":"Roger G.","family":"Evans","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program, Biosciences Discovery Institute and Department of Physiology, Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3318-5406","authenticated-orcid":false,"given":"James T.","family":"Pearson","sequence":"additional","affiliation":[{"name":"Cardiovascular Disease Program, Biosciences Discovery Institute and Department of Physiology, Monash University, Melbourne, Australia"},{"name":"Department of Cardiac Physiology, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce S.","family":"Gardiner","sequence":"additional","affiliation":[{"name":"School of Engineering and Information Technology, Murdoch University, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Smith","sequence":"additional","affiliation":[{"name":"Faculty of Engineering and Mathematical Sciences, The University of Western Australia, Perth, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","first-page":"488","volume-title":"Encyclopaedia of Mathematics","author":"Anonymous","year":"2010"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1109\/34.295913"},{"key":"B3","first-page":"74","volume":"2","author":"Anderson WP","year":"1995","journal-title":"Blood Press Suppl"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/533452a"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1109\/SMI.2010.25"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(91)90020-C"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/450341"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/BF01386390"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.2399\/ana.09.009"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4471-2810-6_9"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.1.440"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00544.2010"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00186.2012"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32836400b2"},{"key":"B16","doi-asserted-by":"crossref","unstructured":"Gross JL, Yellen J. 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