{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:08:59Z","timestamp":1780412939206,"version":"3.54.1"},"reference-count":41,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["5K12HD047349"],"award-info":[{"award-number":["5K12HD047349"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["5R01DK122986"],"award-info":[{"award-number":["5R01DK122986"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["5K08GM144788"],"award-info":[{"award-number":["5K08GM144788"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["5R35GM137958"],"award-info":[{"award-number":["5R35GM137958"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>This two-hit murine model of viral-primed sepsis-associated acute kidney injury (SA-AKI) offers a novel and clinically relevant platform to dissect the immunopathogenic mechanisms linking viral-bacterial coinfections to severe kidney injury. By mirroring features of hyperinflammation and immune dysregulation seen in critically ill patients with SARS-CoV-2, influenza, and other viral infections, this model enables investigation of distinct viral-mediated inflammatory endotypes of SA-AKI, which may guide future efforts to develop targeted, endotype-specific therapies.<\/jats:p>","DOI":"10.1152\/ajprenal.00342.2025","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T18:23:46Z","timestamp":1779301426000},"page":"F761-F771","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel two-hit murine model of viral-primed sepsis-associated acute kidney injury"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7269-617X","authenticated-orcid":false,"given":"James D.","family":"Odum","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacynta A.","family":"Vollmer","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juheb","family":"Akhter","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karly","family":"Laprocina","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3753-1994","authenticated-orcid":false,"given":"Robert P.","family":"Richter","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2233-1711","authenticated-orcid":false,"given":"Jillian R.","family":"Richter","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4276-5186","authenticated-orcid":false,"given":"Anupam","family":"Agarwal","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4650-3151","authenticated-orcid":false,"given":"Subhashini","family":"Bolisetty","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2403213"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000006135"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.1932erratum"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0000000000000753"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-023-07171-z"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0000000000001178"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-04877-4"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00683-3"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05940-8"},{"key":"B10","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.k4891","volume":"364","author":"Poston JT","year":"2019","journal-title":"BMJ"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04628-x"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1820704116"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.585146\/full"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0520-2"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1038\/nature04734"},{"key":"B16","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"National Research Council (US). Committee for the Update of the Guide for the Care and Use of Laboratory Animals.","year":"2011","edition":"8"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.11.005"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.02.196"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1159\/000545776"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.601625"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2012.11.001"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2010.16"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/2211-5463.13851"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094366"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050491"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004100820"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.01.002"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603082103"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05745-w"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080091"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115026"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.01.024"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110625"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052497"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e318220586e"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-017-2990-z"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-0774"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1159\/000508857"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318168ccd5"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000084842.66153.5A"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.07.047"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00342.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:20:19Z","timestamp":1780410019000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajprenal.00342.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,1]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1152\/ajprenal.00342.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00342.2025","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,1]]},"assertion":[{"value":"2025-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}