{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:03:11Z","timestamp":1790614991119,"version":"4.1.0"},"reference-count":33,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health (FNIH)","doi-asserted-by":"publisher","award":["DK44863"],"award-info":[{"award-number":["DK44863"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health (FNIH)","doi-asserted-by":"publisher","award":["DK058816"],"award-info":[{"award-number":["DK058816"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health (FNIH)","doi-asserted-by":"publisher","award":["DK090728"],"award-info":[{"award-number":["DK090728"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association (AHA)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001463","name":"American Society of Nephrology (ASN)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001463","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2015,2,1]]},"abstract":"<jats:p> Vasopressin and V2 receptor signaling promote polycystic kidney disease (PKD) progression, raising the question whether suppression of vasopressin release through enhanced hydration can delay disease advancement. Enhanced hydration by adding 5% glucose to the drinking water has proven protective in a rat model orthologous to autosomal recessive PKD. We wanted to exclude a glucose effect and explore the influence of enhanced hydration in a mouse model orthologous to autosomal dominant PKD. PCK rats were assigned to normal water intake (NWI) or high water intake (HWI) groups achieved by feeding a hydrated agar diet (HWI-agar) or by adding 5% glucose to the drinking water (HWI-glucose), with the latter group used to recapitulate previously published results. Homozygous Pkd1 R3277C ( Pkd1<jats:sup>RC\/RC<\/jats:sup>) mice were assigned to NWI and HWI-agar groups. To evaluate the effectiveness of HWI, kidney weight and histomorphometry were assessed, and urine vasopressin, renal cAMP levels, and phosphodiesterase activities were measured. HWI-agar, like HWI-glucose, reduced urine vasopressin, renal cAMP levels, and PKD severity in PCK rats but not in Pkd1<jats:sup>RC\/RC<\/jats:sup> mice. Compared with rat kidneys, mouse kidneys had higher phosphodiesterase activity and lower cAMP levels and were less sensitive to the cystogenic effect of 1-deamino-8-d-arginine vasopressin, as previously shown for Pkd1<jats:sup>RC\/RC<\/jats:sup> mice and confirmed here in Pkd2<jats:sup>WS25\/\u2212<\/jats:sup> mice. We conclude that the effect of enhanced hydration in rat and mouse models of PKD differs. More powerful suppression of V2 receptor-mediated signaling than achievable by enhanced hydration alone may be necessary to affect the development of PKD in mouse models. <\/jats:p>","DOI":"10.1152\/ajprenal.00345.2014","type":"journal-article","created":{"date-parts":[[2014,12,10]],"date-time":"2014-12-10T22:36:45Z","timestamp":1418251005000},"page":"F261-F266","source":"Crossref","is-referenced-by-count":49,"title":["Effects of hydration in rats and mice with polycystic kidney disease"],"prefix":"10.1152","volume":"308","author":[{"given":"Katharina","family":"Hopp","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ye","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda V.","family":"Irazabal","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.","family":"Harris","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente E.","family":"Torres","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006010052"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.213256"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010111173"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(01)00328-5"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070381"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm141"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nm935"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1520-6408(1999)24:3\/4<309::AID-DVG14>3.0.CO;2-5"},{"key":"B10","author":"Hopp K","journal-title":"J Am Soc Nephrol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1172\/JCI64313"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.193.207"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00473.x"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr069"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20655"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006030251"},{"key":"B17","first-page":"333","volume":"33","author":"Robertson GL","year":"1997","journal-title":"Recent Prog Horm Res"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(07)70046-0"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00790209"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205511"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01743.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013040398"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60601-1"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nm1004"},{"key":"B25","first-page":"361A","author":"Wang X","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2004121090"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.438"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007060688"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.199"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/ng833"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0735-4"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002294"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81570-6"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00367.2004"}],"container-title":["American Journal of Physiology-Renal Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajprenal.00345.2014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T21:09:12Z","timestamp":1567976952000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajprenal.00345.2014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,1]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,2,1]]}},"alternative-id":["10.1152\/ajprenal.00345.2014"],"URL":"https:\/\/doi.org\/10.1152\/ajprenal.00345.2014","relation":{},"ISSN":["1931-857X","1522-1466"],"issn-type":[{"value":"1931-857X","type":"print"},{"value":"1522-1466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,1]]}}}