{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T20:36:48Z","timestamp":1785789408185,"version":"3.56.0"},"reference-count":46,"publisher":"American Physiological Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Renal Physiology"],"published-print":{"date-parts":[[2012,5,15]]},"abstract":"<jats:p>Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disease characterized by massive enlargement of fluid-filled cysts in the kidney. However, there is no effective therapy yet for this disease. To examine whether ginkgolide B, a natural compound, inhibits cyst development, a Madin-Darby canine kidney (MDCK) cyst model, an embryonic kidney cyst model, and a PKD mouse model were used. Interestingly, ginkgolide B significantly inhibited MDCK cyst formation dose dependently, with up to 69% reduction by 2 \u03bcM ginkgolide B. Ginkgolide B also significantly inhibited cyst enlargement in the MDCK cyst model, embryonic kidney cyst model, and PKD mouse model. To determine the underlying mechanisms, the effect of ginkgolide B on MDCK cell viability, proliferation, apoptosis, chloride transporter CFTR activity, and intracellular signaling pathways were also studied. Ginkgolide B did not affect cell viability, proliferation, and expression and activity of the chloride transporter CFTR that mediates cyst fluid secretion. Ginkgolide B induced cyst cell differentiation and altered the Ras\/MAPK signaling pathway. Taken together, our results demonstrate that ginkgolide B inhibits renal cyst formation and enlargement, suggesting that ginkgolide B might be developed into a novel candidate drug for ADPKD.<\/jats:p>","DOI":"10.1152\/ajprenal.00356.2011","type":"journal-article","created":{"date-parts":[[2012,2,16]],"date-time":"2012-02-16T07:14:47Z","timestamp":1329376487000},"page":"F1234-F1242","source":"Crossref","is-referenced-by-count":24,"title":["Ginkgolide B inhibits renal cyst development in in vitro and in vivo cyst models"],"prefix":"10.1152","volume":"302","author":[{"given":"Hong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Basic Medical Sciences, Peking University and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsheng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Basic 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