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The effect of 2\u2032-PP on serum phosphate, serum PTH, serum total Ca<jats:sup>2+<\/jats:sup>, and ionized Ca<jats:sup>2+<\/jats:sup>, Ca<jats:sup>2+<\/jats:sup>\u00d7 P<jats:sub>i<\/jats:sub>product, urine protein, urine osmolality, and creatinine clearance in 5\/6 NX rats was examined. Uremic rats in chronic renal failure were gavaged daily with 25 \u03bcM 2\u2032-PP. Over the course of a 5-wk experiment, serum chemistry in untreated uremic rats, 2\u2032-PP-treated uremic rats, and age-matched control rats with normal renal function was determined twice a week. Urine creatinine, urine osmolality, urine phosphate, and urine protein were determined once a week from 24-h collections. 2\u2032-PP reduced serum phosphate 40 \u00b1 3% compared with a 17% increase in untreated uremic control rats. 2\u2032-PP did not alter total serum Ca<jats:sup>2+<\/jats:sup>. During 5-wk experiments, serum PTH increased 65 \u00b1 25% in untreated uremic rats and decreased 70 \u00b1 7% in uremic rats treated with 25 \u03bcM 2\u2032-PP. Creatinine clearance decreased 20% in untreated uremic rats compared with a 100% increase in 2\u2032-PP-treated uremic rats. Urine protein decreased and urine osmolality increased in uremic rats treated with 2\u2032-PP. The mechanism of the effect of 2\u2032-PP on serum phosphate was inhibition of intestinal phosphate absorption. 2-PP inhibited intestinal phosphate absorption 50% without altering dietary protein absorption or intestinal Ca<jats:sup>2+<\/jats:sup>absorption. Over the course of the 5-wk treatment with 2\u2032-PP, uremic animals treated with 2\u2032-PP had a 2\u20134% weight gain\/wk, similar to the weight gain seen in age-matched control rats with normal renal function.<\/jats:p>","DOI":"10.1152\/ajprenal.00360.2003","type":"journal-article","created":{"date-parts":[[2004,2,10]],"date-time":"2004-02-10T01:13:40Z","timestamp":1076375620000},"page":"F48-F56","source":"Crossref","is-referenced-by-count":5,"title":["Effect of 2\u2032-phosphophloretin on renal function in chronic renal failure rats"],"prefix":"10.1152","volume":"287","author":[{"given":"B. E.","family":"Peerce","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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